Homework Answers
The answer is option C
Cyclobutane thymine dimer cannot be repaired by Base excision repair.
The cyclobutane thymine dimer is a DNA lesion produced in the skin and is major cause for skin cancer.
The cellular epidermis is rich in UV absorbing chromophores (nuclear DNA being the most important) and are highly vulnerable to photodamage.
The dimers form when the C5=C6 double bond splits after absorbing UVR and links the two dimers at C5 and C6 positions.
The photodamage of DNA is very common and most organisms have elaborate DNA repair mechanisms.
Nucleotide excision repair is the most important one in human skin.This uses various enzymes for recognition of DNA photolesions using the opposite strand as template.
Base excision repair repairs the damage to to non-distorting single base modification caused by oxidation. Thus, it cannot repair the Cyclobutane thymine dimer lesion which is a distorted lesion.
DNA photolyase uses blue light to repair the diner lesion, by splitting the cyclobutane into two normal bases.
Thus, the wrong statement is that the Cyclobutane thymine dimer can be repaired by Base excision repair(BER).
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Question 3 3 pts Which statement is wrong about cyclobutane thymine dimmer. caused by UV damage....
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can you guys please give me the correct answers and explain
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3. Which of the following statements is CORRECT? A. Exposure of E.coli to UV light greatly increases the frequency of cytosine deamination B. Mutagens that intercalate into the double helix lead to the formation of thymine dimers. C) Oxidative damage to DNA usually leads to the formation of frameshift mutations. D. Some alkylating agents are mutagenic because they chemically modify amino acids in the active site of DNA...
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Question 5 1 pts The condition, xeroderma pigmentosum, is caused by dimerization of thymine bases when UV damage to DNA is not repaired. What mechanism exists to repair this kind of damage to DNA? proofreading nucleotide mismatch repair nucleotide excision repair phosphodiester substitution Question 6 1 pts Information obtained by Franklin from X-ray crystallography on DNA suggested that it is a
Repair of DNA damage from UV radiation
DNA damage from UV radiation needs to be repaired if
DNA replication occurs without error. the following plot shows how
cell survival is affected in the presence of UV radiation. Notice
that the wild-type cells can overcome the damaging effects of UV
radiation on DNA and show high survival even as UV increases.
However, cells deficient in certain genes display relatively much
lower survival rates.
1. the fact that the double mutant shows...
Ul Ehé question paper. 1. Mutations can be caused by: a) tautomeric shifts b) UV light c) chemical changes to bases such as deaminatior C) all the above 2. The start of a wild type mRNA was AUGCCCAAGAccA mu tation This type of change resulted in the sequence AUGUCCAAGACC. is called a a) missense一®.frameshift mutation. 3. The typical rate of mutation for a human gene is per generation. a) 103 c) 10 d) 10-11 e) 104 4. If a hypothetical...
can you guys please give me the correct answers and explain
why?
3. Which of the following statements is CORRECT? A. Exposure of E.coli to UV light greatly increases the frequency of cytosine deamination B. Mutagens that intercalate into the double helix lead to the formation of thymine dimers. C) Oxidative damage to DNA usually leads to the formation of frameshift mutations. D. Some alkylating agents are mutagenic because they chemically modify amino acids in the active site of DNA...
and Lab Exer n this experiment you will evaluate effect of UV light on bacterial growth. UV light affects growth by interfering with DNA, resulting in thymine dimer formation. The dimerization is confined within adjacent thymine residues on same strand (intrastrand ). These dimmer lesions have consequence on DNA functions including interference in DNA replication, transcription etc, so UV exposure of cells can lead to lethal effects for bacterial multiplications. This forms the basis for UV method to control bacterial...
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Question 5 1 pts Non-homologous end joining is "error prone" because There is no template used during repair The DNA polymerase invovled adds incorrect bases ODNA ends are often trimmed before repair Damaged bases are incorrectly paired during repair Question 6 1 pts Global genomic and transcription coupled are the two sub-types of nucleotide excision repair. Select true statements relevant to these processes Both can detect damage involving multiple damaged bases Both involve proteins that recognize the damaged bases Both...
17. A diploid plant is a dihybrid for flower color (gene “R”)
and leaf size (gene “L”). Its
phenotype is red flowers and large leaves. This plant is crossed to
a tester plant (which has
white flowers and small leaves). The progeny is as follows:
23 Red, large
25 White, small
230 Red, small
235 White, large
What can be concluded about the linkage relationship of the loci in
the dihybrid parent?
A) Genes R and L are unlinked
B)...
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