Question

Repair of DNA damage from UV radiation

DNA damage from UV radiation needs to be repaired if DNA replication occurs without error. the following plot shows how cell survival is affected in the presence of UV radiation. Notice that the wild-type cells can overcome the damaging effects of UV radiation on DNA and show high survival even as UV increases. However, cells deficient in certain genes display relatively much lower survival rates.

1. the fact that the double mutant shows the lowest survival suggests that nucleotide excision and recombinational DNA repair systems _________
Select all that apply.
____ are both required for any DNA repair to occur.
_____ do not increase cell survival following DNA damage.
________ function independently of one another.
________ do not function in wildtype cells
_________ function in the same pathway of repair.

please help

Answer 1

The uvrA is required for nucleotide excision repair, and the recA is required for recombinational DNA repair. Double mutant of uvrA and recA showing the lowest survival on exposure to UV compared to their respective single mutants shows that these two pathways function independently of one another