Question

How are prions, such as PrPSc, an example of epigenetic inheritance?

Answer 1

to Prions are transmit of the samme protein. They transmissible other such as in cervids ete. page-1 misfold proteins with the ability their misfold shape onto normal varients characterize several fetal and neurodegenerative diseases in humans and mang animals. Par Pse (sear scrapie isoform of the prion protein) prsions are the infections agent behind disease Creutzfeldt - Jakob disease in a humans, bovine songiform encephalopathy in cattle, chronic wasting disease Ro Piripse is an alter natively folded varient of the cellulas prion protein, B Porpe which is anchored protein that is present on the cell surface of u neurons and other cell types. Transmissible spongiform encepha pathies publie attention because of bovine sporgiform encephalopathy in eattle and its possible link to Greutzteldt- Takob disease in human. too ways to view tais process! As an epi genetie inheritance system in Jablonka inheritance system and Lamb's terms a cell structure acts as a template for new. In this a regular , GoPI come to There are a structural in which

case which an may provide تعليمه t Page 2 the aberrant prion acts as a template to normal pron protein is tansformed. The folding of heat shock protein 60 analogaus, thought functional example. As the creplication of a biological entity (ie. the prion protein a distinct biological organisms ) in its The ability to be transmitted between biologically unore lated organisms and even between organisms of different species, suggests that is it is more helpful to view the aberrant prion as seperate replieating entity rather rather than the product of a rogue cellular epigenetie inheritance mechanism. It In this view the infectious prion is an obligate parasite analogow a viro virus. However, unlike virus, which pass genetie information onto its progeny, the infections prion pass only structural information onto its progeny As prion lack suckie allt, it is an obligate epigenetic Inheritorer the the
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