Question

What would be the consequence of the loss of the gene that encodes glycogenin in the liver? Liver glycogen will be less readily degraded. (The mobilization of liver glycogen will be impaired.) Glycogen will not be degraded unless a hormone induced pathway coverts the phosphorylase. Very little glycogen will be synthesized. Little glycogen would be present in the liver due to increased degradation.

Answer 1

1) Glycogenin is an enzyme which is responsible for the synthesis of Glycogen in the liver. Glycogenin converts the excess glucose in the blood to Glycogen and stores in liver. The gene for Glycogenin-1 is GYG-1. The mutation in GYG-1 gene makes it function less and causes reduced glycogen synthesis in liver mediated by Glucagon, etc.

Hence, option (3) very little glycogen is synthesised is the answer.