Question

4. This question is in reference to Table 1 found in Section 3 "Scientific Results in Support of Thalidomide Victims." Based on the results, what can you conclude about the teratogenicity of the racemic mixture versus R/S enantiomers of thalidomide?

5. This question is in reference to Table 2 found in Section 3 "Scientific Results in Support of Thalidomide Victims." What can you conclude about the inversion rate for the two enantiomers?

6. The rate of inversion 0.5 (hr-1) corresponds to 5 inversions in one hour. How many inversions occurred an hour for thalidomide as reported in Table 2 from R to S and from S to R?

please give a detailes explanation thank you.

4. (1 pt.) This question is in reference to Table 1 found in Section 3 "Scientific Results in Support of Thalidomide Victims". Based on the results, what can you conclude about the teratogenicity of the racemic mixture versus R/S enantiomers of thalidomide? 5. (1 pt.) This question is in reference to Table 2 found in Section 3 "Scientific Results in Support of Thalidomide Victims". What can you conclude about the inversion rate for the two enantiomers? 6. (1 pt.) The rate of inversion of 0.5 (hr) corresponds to 5 inversions in one hour. How many inversions occurred an hour for thalidomide as reported in Table 2 from R to and from Sto R?

Answer 1

(4.) Teratogeneity Page 0 solution is the ability of a dry interfed with the development of a fetus, binth defects. On table : The rasemic mixture thalidomide to given 6 rabbits and they produced is normal fehesses and malformed feturses 25 + 10 = 35 total no. of Jetus Terabeganie 1.. 40 x100 Rs of was. 25 lo r. 28.571 35 were RE) enantiomen_given to 7 rabbits and 46 Jetusse f rabite were found normal and malformed 46 48=54 total no of getuses 14.81 Z XL00_2 54 8 Jetuses were 의 were SL enantiomere given to rabbits and 56 normal and malformed 5649=65 total mo. of Jetusen 13 85 % 9 X 100 65 On comparison mou ther of teratogeneity, the CR, s.) ralemie mixture teratogenic with 28:52 than RH (14.81%) St-J (13.85%) enantiomers. I we may conclude the (R, 5l nasimie mixture is Very teratogenic than enantiomers and

5. The (R)-enantiomer of Thalidomide has sedative effects, whereas the (S)-isomer is teratogenic. Now, the k_RS=0.30 and k_SR= 0.31 that means the rate of the S to R formation is higher than the rate of R to S formation. So, according to the inversion constant, there may be an accumulation of R isomer, but accumulation of S isomer is not possible.

6. R to S is 3 inversions in one hour

S to R is 3.1 inversions per hour