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Can you please help me with this problem:

2. If the new mutation rate for Retinoblastoma (an autosomal dominant disease) is 20 mutations per 106 gametes, and there are

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Answer #1

1 birth requires 2 gametes.

50,000 births will require 2 × 50,000 = 1,00,000 gametes = 10^5

10^6 gametes = 20 mutations

10^5 gametes = 20/10^6 × 10^5 = 2 mutations

So, 10^5 gametes or 50,000 births will show 2 mutations.

Hence, out of 50,000 births, 2 will have retinoblastoma.

Please ratr high.

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