Which is the correct sequence of the Ras pathway A. Ras → SOS → Raf →...
Which is the correct sequence of the Ras pathway
A. Ras → SOS → Raf → MEK → MAP kinase → Jun
B. SOS → Ras → Raf → MEK → MAP kinase → Jun
C. SOS → Raf → Ras → MEK → MAP kinase → Jun
D. SOS → Ras → MEK → Raf → MAP kinase → Jun
Homework Answers
Option B.
When an external signal stimulates the receptor tyrosine kinase, it's autophosphorylation leads to recruitment of Grb2 and Sos. This activates Ras and RAF binds to binding domain of Ras. This allows subsequent activation of MEK and ERK (Map kinase).
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Which is the correct sequence of the Ras pathway
A. Ras → SOS → Raf →...
2. The following is a description of a signaling pathway initiated by receptor tyrosine kinases. Ligand → RTK → Sos → Ras → Raf → MEK → ERK → Transcription factor → Cell growth A. (3pts) Which of the...
2. The following is a description of a signaling pathway initiated by receptor tyrosine kinases. Ligand → RTK → Sos → Ras → Raf → MEK → ERK → Transcription factor → Cell growth A. (3pts) Which of these steps indicates the protein is activated after a GTP exchange step? B. (3pts) Which of these proteins can be deactivated by phosphatases? C. (4pts) Describe a mutation that would cause Ras to be permanently "on"? Would this mutation lead to high...
Like the Ras protein itself, the various components of the Ras signaling pathway are changed in...
Like the Ras protein itself, the various components of the Ras signaling pathway are changed in cancer cells. What might be the biochemical consequence of mutations in the genes coding for (a) Raf and (b) MAP kinase that result in rapid cell division?
Match key players to the specific pathway v GPCR A. Raf, Ras NRTK B. SMAD ~...
Match key players to the specific pathway v GPCR A. Raf, Ras NRTK B. SMAD ~ RTK C. STAT TGFb D. none Wnt E. Frizzled
help with 38 I got it wrong and dont know what it is what is ras?...
help with 38 I got it wrong and dont know what it
is
what is ras? is what is missing sorry
lilleonine kinase receptors D) Nuclear receptors E) Tyrosine phosphatase receptors D 37. Which one (if any) of the following cellular events does NOT inci wing cellular events does NOT include a role for apoptosis: A) Immune function return to homeostasis following an infection B) Digit formation during development C Cellular response to irreparable DNA damage identified in G1 of...
Uncontrolled growth is a necessary step for the development of all cancers. Which of the following...
Uncontrolled growth is a necessary step for the development of all cancers. Which of the following drugs, that target the MAP/ERK pathway (EGF receptor pathway), could inhibit uncontrolled cell growth? Drugs that bind and activate the EGF receptor Drugs that inactivate protein kinase A (PKA) Drugs that block the phosphorylation of Mek Drugs that block the inactivation of the RAS g-protein
Pls give short answers. Thank you Q5 EGF pathway 23 Points A EGF EGFR GRB2 SOS...
Pls give short answers. Thank you
Q5 EGF pathway 23 Points A EGF EGFR GRB2 SOS KRAS Active RAS KRAS GOP GDP GTP RAF РІЗК MEK АКТ) ERK Growth and Suppression Proliferation of Apoptosis Shown is the EGF signaling pathway. This is a pathway that normally promotes growth during development, and inhibits apoptosis (or programmed cell death). This pathway is also involved in cancer. Epidermal growth factor (EGF) binds to its receptor (EGFR). This binding activates the protein KRAS, which...
A complex signaling pathway in yeast allows the cells to accumulate high concentrations of glycer...
A complex signaling pathway in yeast allows the cells to accumulate high concentrations of glycerol if they are exposed to high extracellular concentration of salt or glucose. The increased osmolarity of the extracellular medium activates Ras, which in turn activates adenylate cyclase. A second pathway, the HOG (high osmolarity glycerol) pathway activates the MAP kinase pathway. The target protein is the enzyme PFK2, which is activated by phosphorylation. (PFK2 produces an allosteric regulator that activates glycolysis, which ultimately produces glycerol.)...
Classes 7-8 Cytoplasmic Growth Signaling Be able to describe Ras structure and function. What kind of...
Classes 7-8 Cytoplasmic Growth Signaling Be able to describe Ras structure and function. What kind of protein is it? How is it regulated (Fig. 5.30)? How many forms of Ras do humans express? Be able to describe how Ras interacts with multiple downstream partners. What mechanisms render ras oncogenic? Also, how does Ras become oncogenic in the absence of ras mutations? Be able to describe how Ras interacts with the growth factor receptor signaling machinery. How did fly genetics help...
2A. Using the figure below, label and describe how Raskets activated (define GEF and GAP in...
2A. Using the figure below, label and describe how Raskets activated (define GEF and GAP in your answer) C -GTP 23. Describe two points at which the signaling of Ras can be dysregulated to allow Ras to be constitutively activated, allowing continuous signaling to downstream effectors. 5 2C. Briefly, Describe one of the following two pathways downstream of activated Ras (PI3K/PTEN or Raf/MEK/ERK), describing how that specific pathway promotes cancer by discussing each schematic P Rat MAP3K 3 PMEKUZ MAP2K...
, ras-, Rat-, MEK-, MAPK. / 4. What determines the sensitivity of a cell to a...
, ras-, Rat-, MEK-, MAPK. / 4. What determines the sensitivity of a cell to a signaling ligand? a. The number of receptor proteins in the plasma membrane. b. The ligand concentration. c. The Kd of the receptor for a ligand. d. All of the above e. None of the above. 5. In the "fight or flight" response, epinephrine stimulation of muscle cells: a. inactivates Glycogen Phosphorylase Kinase (GPK). b. inactivates Glycogen Synthase (GS) c, activates Phosphoprotein Phosphatase 1 (PP1)....
2. The following is a description of a signaling pathway initiated by receptor tyrosine kinases. Ligand → RTK → Sos → Ras → Raf → MEK → ERK → Transcription factor → Cell growth A. (3pts) Which of these steps indicates the protein is activated after a GTP exchange step? B. (3pts) Which of these proteins can be deactivated by phosphatases? C. (4pts) Describe a mutation that would cause Ras to be permanently "on"? Would this mutation lead to high...
Match key players to the specific pathway v GPCR A. Raf, Ras NRTK B. SMAD ~ RTK C. STAT TGFb D. none Wnt E. Frizzled
help with 38 I got it wrong and dont know what it
is
what is ras? is what is missing sorry
lilleonine kinase receptors D) Nuclear receptors E) Tyrosine phosphatase receptors D 37. Which one (if any) of the following cellular events does NOT inci wing cellular events does NOT include a role for apoptosis: A) Immune function return to homeostasis following an infection B) Digit formation during development C Cellular response to irreparable DNA damage identified in G1 of...
Pls give short answers. Thank you
Q5 EGF pathway 23 Points A EGF EGFR GRB2 SOS KRAS Active RAS KRAS GOP GDP GTP RAF РІЗК MEK АКТ) ERK Growth and Suppression Proliferation of Apoptosis Shown is the EGF signaling pathway. This is a pathway that normally promotes growth during development, and inhibits apoptosis (or programmed cell death). This pathway is also involved in cancer. Epidermal growth factor (EGF) binds to its receptor (EGFR). This binding activates the protein KRAS, which...
Classes 7-8 Cytoplasmic Growth Signaling Be able to describe Ras structure and function. What kind of protein is it? How is it regulated (Fig. 5.30)? How many forms of Ras do humans express? Be able to describe how Ras interacts with multiple downstream partners. What mechanisms render ras oncogenic? Also, how does Ras become oncogenic in the absence of ras mutations? Be able to describe how Ras interacts with the growth factor receptor signaling machinery. How did fly genetics help...
2A. Using the figure below, label and describe how Raskets activated (define GEF and GAP in your answer) C -GTP 23. Describe two points at which the signaling of Ras can be dysregulated to allow Ras to be constitutively activated, allowing continuous signaling to downstream effectors. 5 2C. Briefly, Describe one of the following two pathways downstream of activated Ras (PI3K/PTEN or Raf/MEK/ERK), describing how that specific pathway promotes cancer by discussing each schematic P Rat MAP3K 3 PMEKUZ MAP2K...
, ras-, Rat-, MEK-, MAPK. / 4. What determines the sensitivity of a cell to a signaling ligand? a. The number of receptor proteins in the plasma membrane. b. The ligand concentration. c. The Kd of the receptor for a ligand. d. All of the above e. None of the above. 5. In the "fight or flight" response, epinephrine stimulation of muscle cells: a. inactivates Glycogen Phosphorylase Kinase (GPK). b. inactivates Glycogen Synthase (GS) c, activates Phosphoprotein Phosphatase 1 (PP1)....
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