Question

How would scaffold protein confer specificity?

Answer 1

Scaffold proteins have the capability to bond to many proteins, which are involved in a particular signaling pathway. They can bind simultaneously, and are also key regulators. It confers specificity by binding to the molecules that are involved in the reaction, such as binding to the enzyme and its subtrate. For example, they may bind to the kinase enzyme, and its substrate, so that it can ensure the phosphorylation reaction.