Question

When neurotransmitters bind to metabotropic receptors, they bind to the _________ of the receptor, causing the...

When neurotransmitters bind to metabotropic receptors, they bind to the _________ of the receptor, causing the receptor to change shape, which is the first step in an intracellular signaling cascade. One essential neurotransmitter, acetylcholine, can generally exert excitatory effects when binding to its ionotropic receptors but can have either excitatory or inhibitory effects when binding to _____________ receptors. When neurotransmitters like acetylcholine bind to _________ receptors they let ions (e.g. Na+, Cl-) into the neuron directly through that channel they are binding to.

Group of answer choices

External component; muscarinic; ionotropic

Internal component; muscarinic; ionotropic

Internal component; nicotinic; metabotropic

External component; nicotinic; metabotropic

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Answer #1

Option A is correct. G protein-coupled receptors are inherently metabotropic receptors. Neurotransmitters bind to receptors to the external component and activate cascade of events intracellularly. It involve asa range of secondary messangers.

Another type of receptors are ionotropic. It opens a chhanel that allows ions(Na+, K+ or Cl-) to flow.

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