Question

Acyl Carrier Protein (ACP) is needed in fatty acid biosynthesis resembles which cofactor that is involved in fatty acid catabolism?

A.

TPP

B.

Folic acid

C.

Coenzyme A

D.

FAD

E.

NAD⁺

F.

None of the above

Answer 1

Ans:

C. Coenzyme A

Explanation: Coenzyme A consists of pantothenic acid which is responsible for acyl groups. This pantothenic acid is also a component of acyl carrier protein (ACP). So, ACP is resemblance with coenzyme A. This ACP is required in fatty acid biosynthesis because all the intermediates of this biosynthetic pathway are covalently bound to ACP and  transports the growing fatty acid chain between enzyme domains of fatty acid synthase. In the first step of fatty acid catabolism, The fatty acids are activated by the coenzyme A. TPP (Thiamine pyrophosphate) is composed of a thiazole rings joined with a pyrimidine by methyl bridge and act as cofactors in the oxidative decarboxylation of $\alpha$ -keto acid. Folic acid is consists of a pterin ring attached to para aminobenzoic acid and glutamic acid and it plays important role in the transfer of carbon units and biosynthesis of certain amino acids. FAD is composed of riboflavin,  isoalloxazine ring and phosphate while NAD+ composed of nicotinic acid. This FAD and NAD+ are serve as coenzyme in glycolysis, TCA cycle and electron transport chain.