Question

The mode of inheritance for this pedigree is autosomal dominant.

1 1 N II 1 3 4 5 6 N = 1 2 3 4 5 6

If I-1 and II-2 were to have another child, what is the probability that their child would express the trait? Explain.

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aa Aa I 1 2 aa aa АО Aa aa IL 1 2 3 u 5 6 aa aa Aa АО 피 O АО 1 2 مرا 5 6

As it is a Autosomal Dominant inheritance trait, the unaffected individual will be homozygous recessive (aa) for the trait and affected Individual will be having heterozygous dominant (Aa) or homozygous dominant (AA) for the trait.

If I-1 & II-2 were to have a child, the probability that their child would express the trait is zero. As they both are homozygous recessive allele.

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