Question

Provide two reasons why identification of DNA variants in cancer patients is relatively easy compared to other disease phenotypes, such as intellectual disability.

Answer 1

Cancer therapy is used to abnormalities within the cancer cells The genes and proteins have to normally keeps the cell division under control, but damaged in tumor cells.

In the DNA varients in cancer patient identification SNP and De-Nova mutation in intellectual disability;

1. SNP is the single nucleotide polymorphism.Genome Rearrangements are Detected by the SNP Microarrays in Individuals with the Intellectual Disability Referred to the Williams Syndrome . Intellectual disability is affects 2–3% of the people  and may occurs with  other medical conditions...

2. De-Nova mutation ,Genetics are  believine  to the important role of the intellectual disability,   The involvement of de novo mutations in Intellectual disability but they contributes to the pathogenesis and identified corresponding genes. then we reported a screen for De-Nova Mutations in subjects with the moderate ID.then sequencing the exomes are  41 pro bands to their parents, confirmed 81 DNMs affecting the coding sequence .