Homework Answers
a) In this question, the disease is said to be X-linked recessive, meaning two diseased alleles are needed on the X-chromosome. Now, both the women gentypes for the microsatellite has M1/M1 (homozygous condition) and M1/M2 (heterozygous condition) without the disease. So it is obvious that M1 loci when present in homozygous or heterozygous is not responsible for the disease. The disease microsatellite is M2. The genotype of IV-4 is M2/Y (since he is a man having only one X chromosome)
b) The disease and the microsatellite loci are 10cM apart. So recombination frequency between them in 10.% thus the disease loci and microsatellite loci are linked. IV-4 has unaffected parents but the mother is heterozygous. Let us consider the Punnet square:
| M1 | M2 | |
| M1 | M1M1 | M1M2 |
| Y | M1Y | M2Y |
So the two possible genotypes is M1Y and M2Y and the possible genotype must be M2Y and the disease loci and microsatellite loci is linked.
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The pedigree shows the occurrence of a X linked recessive mendelian disease in a human family....
The pedigree below that shows a family in which an autosomal recessive disorder is present. Family...
The pedigree below that shows a family in which an autosomal recessive disorder is present. Family members 1-2 and II-2 are affected by the disorder and have the genotype dd. A pregnancy involving Il-4 has just undergone genetic testing for a VNTR that is linked to the disease gene. The VNTR has two alleles, V1 and V2. The gel electrophoresis patterns for each family member are shown, including the VNTR genotype for 1|-4. 2 - 2 3 4 = ?...
The pedigree below shows the inheritance pattern of a sex-linked allele for one family. What is...
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pedigree 8. The Addams family knows of three relatives who had Menkes disease, and X-linked recessive...
pedigree
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The pedigree below shows a family with a rare late-onset X-linked disease that is 8 m.u. from the STR locus R5T. The STR genotype is shown below each person. What is the probability II-1 will develop the disease later in life? 2,3 4 3 2,4 Select one: a. 8% b. 46% c. 92% d. O e. 4%
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Part B Determining genotypes in pedigrees of X-linked conditions The pedigree from Part A is shown...
Part B Determining genotypes in pedigrees of X-linked
conditions
The pedigree from Part A is shown below. Fill in the most likely
genotypes of the indicated individuals in the pedigree. Note that a
dominant allele followed by an underscore (_) indicates that either
the dominant or the recessive allele may be present at the second
position. Drag one pink label (for condition A, autosomal
recessive) to each pink target. Drag one blue label (for condition
B, X-linked recessive) to each...
Creating a pedigree chart from a family history and hypothesizing pattern of inheritance A family with...
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10. Red green colorblindness is an X-linked recessive disease. That means that it is carried on...
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NAME: 6. Red-green color deficiency is an X-linked recessive trait. A woman with normal color vision...
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The pedigree below that shows a family in which an autosomal recessive disorder is present. Family members 1-2 and II-2 are affected by the disorder and have the genotype dd. A pregnancy involving Il-4 has just undergone genetic testing for a VNTR that is linked to the disease gene. The VNTR has two alleles, V1 and V2. The gel electrophoresis patterns for each family member are shown, including the VNTR genotype for 1|-4. 2 - 2 3 4 = ?...
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pedigree
8. The Addams family knows of three relatives who had Menkes disease, and X-linked recessive disorder in which a child does not grow, has brain degeneration, and dies by age two. Affected children have peculiar white stubby hair. Wanda Addams is hesitant about having children because her two sisters have each had sons who died from Menkes discase. Her mother had a brother who died of the condition, too. The pedigree for the family is shown below. A. Fill...
Question 3 The following human pedigree shows a family affected by a specific disease. Assume that the individuals marked with an asterisk () do not carry any allele associated with the affected phenotype and that no other mutation spontaneously occurs. Also assume complete penetrance a) State the most likely mode of inheritance for this disease. Choose from: autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive b) Write all possible genotypes of the following individuals in the pedigree. Use the uppercase...
The pedigree below shows a family with a rare late-onset X-linked disease that is 8 m.u. from the STR locus R5T. The STR genotype is shown below each person. What is the probability II-1 will develop the disease later in life? 2,3 4 3 2,4 Select one: a. 8% b. 46% c. 92% d. O e. 4%
93. The pedigree below shows the sex-linked recessive inheritance of Nance-Horan syndrome, a rare Mendelian disorder in which affected persons have cataracts and abnormally shaped teeth. What is the probability that the first child of IV-6 and V-3 would have Nance-Horan syndrome? Iv A) 114 B) 1/2 C) 1/8 D) 3/16 E) 3/4
Part B Determining genotypes in pedigrees of X-linked
conditions
The pedigree from Part A is shown below. Fill in the most likely
genotypes of the indicated individuals in the pedigree. Note that a
dominant allele followed by an underscore (_) indicates that either
the dominant or the recessive allele may be present at the second
position. Drag one pink label (for condition A, autosomal
recessive) to each pink target. Drag one blue label (for condition
B, X-linked recessive) to each...
Creating a pedigree chart from a family history and hypothesizing pattern of inheritance A family with a new disease caused by a mutant gene has been found. The family history has been collected and recorded. You will now create a pedigree chart from their family history and use the pedigree to predict the pattern of inheritance the disease follows. • Read the following family history: Patient 1 and Patient 2 visited a genetics counselor and provided their family histories. As...
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