Question

Creating a pedigree chart from a family history and hypothesizing pattern of inheritance A family with a new disease caused by a mutant gene has been found. The family history has been collected and recorded. You will now create a pedigree chart from their family history and use the pedigree to predict the pattern of inheritance the disease follows. • Read the following family history: Patient 1 and Patient 2 visited a genetics counselor and provided their family histories. As much as possible, we were also able to confirm their oral histories with death certificates and other medical records, where available. The disease is extremely rare in the general population, but Patient 1 and Patient 2 met at a support group meeting for people affected by the disease. They are engaged to be married next year, and would like to have children in a couple of years. Patient 1 (female) has the disease but Patient 2 does not. Patient l's brother and mother have the disease but her sister and father do not have it. On her mother's side, one of her uncles has the disease but her other uncle and aunt do not. Her mother's father (the patient's grandpa) had the disease but her grandmother did not. Her grandfather's brother and sister did not have the disease nor did his father, but his mother did have it. Patient 2 (male) does not have the disease nor does his brother or sister, but both his parents have it- they were second cousins. On his mother's side, his uncle does not have the disease nor did his grandmother, but his grandfather, one of his grandfather's two sisters, and his grandfather's brother all had it. His great-grandmother was also affected by the disease, but his great-grandfather was not . Using the family history, create a pedigree chart by drawing it on a piece of paper. Unless specified, assume that an individual does not have the disease. Remember to use circles for females and squares for males. If the sex of an individual is unknown, use a diamond. Fill in the shape for individuals with the disease. Once your pedigree is complete, analyze the pattern of inheritance. Based on your analysis, make a hypothesis about which pattern of inheritance the disease appears to follow. Based on the pattern of inheritance you think the disease has, fill in the genotypes of the individuals in the pedigree. Using Punnett squares, check to make sure that there are no cases where the resulting offspring/parent combination is not possible (remember, predicted ratios may not exactly match because of small family size). Change your hypothesis about pattern of inheritance, if necessary Take a picture of your pedigree chart and insert it into this document. .

Answer 1

DATE: pedigree chart 2 САО Aa Аа Aa Аа aa Аа Aa o aa aa aa (Pt. 2) at is Autosomal Dominant ene express only Hete mozygour condition

panent's Not Mentioned DATE: aa Ао, patient Aa Aa aa, Αα Aa Aa Ао. cha Aa (patient-1) Fineust pedigree char (patients ) disorder Autosomal recessive which expresses anly Homozygous Conditions.

Summary:---The first case is a autosomal recessive disorder . Autosomal means that the gene is located on the autosome . Recessive means it expresses only in the Homozygous condition.  

The second case is a autosomal dominant disorder. Dominant disorder express both in the Homozygous and heterozygous condition .

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