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16.Tay-Sachs is an autosomal recessive disease. A couple (Jack & Jill) is worried about having a child that has Tay-Sachs bec
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Answer #1

The disease is autosomal recessive.

Normal = AA, Aa (carrier)

Affected = aa

It is given that the brother of the man was suffering from the disease. It means the genotype of the brother was aa. This is possible only if both the parents were heterozygotes and were having genotype Aa. Individuals with this genotypes are not affected but are Carriers of the disease.

Jack's parents were both Aa.

Gametes A a
A AA normal Aa normal
a Aa normal aa affected

​​​​​The genotype of Jack will there be AA or Aa because he is normal.

The child of Jack and Jill will have the disease only if both Jack and Jill and heterozygotes and have genotype Aa.

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