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The pedigree below shows a family with a rare late-onset X-linked disease that is 8 m.u. from the STR locus R5T. The STR geno

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Answer #1

II-1 is a male and hence got his only X chromosome from his mother, who has not been shown to be a carrier. Therefore the probability of his developing the condition is zero (option d).

However, II-2 is female and got one X from her affected father. Assuming the condition to be dominant, she has a 92% probability of developing the condition later. This is so because the probability of a recombination, wherein she gets the STR locus 4 but not the gene for the condition is 8%.

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Answer #2

This is an X-linked disease. So, the father (I-2) has the affected gene on X chromosome. Mother (I-1) has two X chromosomes (both are normal). Son (II-1) gets his only X chromosome from his mother, whereas he gets Y chromosome from his father.


So, there is no chance for II-1 to get the affected X chromosome from his parents. He will be normal.


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