Question

You are fasting for an experiment in physiology lab and have not eaten since last night. Glucagon is stimulating a signal transduction pathway that results in CAMP. Describe the effects of this glucagon signaling via protein kinase A (PKA) on glycogen and fat metabolism in your liver, skeletal muscle, and adipose cells. What is the relationship between CAMP in your cells and the pseudosubstrate sequence of PKA? Note - It is not necessary to describe the glucagon signal transduction pathway mediated by the G-protein-coupled receptor. BIVA-A-LE 371xx, - XV AT 12pt Paragraph

Answer 1

Glucagon is a hormone which produced by pancrease .It help glucose metabolism and matain the normal blood glucose level.The main function of this hormone convert glycogen ,the stored glucose, into glucose.When blood glucose falls under70mg/100ml glucagon production incresases and glycogen or amino acid convert to glucose.

    Glucagone bind with glucagone receptor and activate the next enzyme adenylate cyclase.Adenylate enzyme help manufature of cyclic adenosine mono phosphate(cAMP),which activate protein kinase A . cAMP help the phosphorelation of glycogen.Which help release of glucose mono phosphate from glycogen molecules.Protein inase bind with cAMP phosphorylate phosphorylase kinase.This complex again phosphorylates phosphorelase.PKA regulate the enzyme fructose 2 6 phosphatase and phosphofertoinase,slowing thhe rate of glycolysis and allowing glycogenisis.glucagone stimulate the PKA for inactivate the enzyme pyruvate kinase in the cells.

The pseudosubtrate sequence bind active site of the enzymes and inhibit the phosphorelation .