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3. Why cant natural selection alone drive dominant alleles to fixation within a population?

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Fixation of dominant allele in a population means, there will be no recessive allele in that population. Only dominant alleles remain in the population.

Natural selection can decrease or increase allele frequency in a population. It can leads to speciation by accumulation of adaptive genetic differences among reproductively isolated populations. Natural selection can increase the frequency of dominant allele and decrease the frequency of recessive allele. But is cannot totally eliminate recessive allele even if the allele is lethal.

Because Homozygous recessive could be eliminated by natural selection but recessive allele will still remain in the population in heterozygous individuals. Heterozygous individuals have dominant phenotype, but they also have recessive alleles. So natural selection cannot drive dominant allele to fixation within a population.

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