Explain what is meant by "lagging strand" of DNA during replication.

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Question

Answer 1

Answer #1

Lagging Strand:

1. Lagging strand is a replicated strand of DNA which is formed in short segments called Okazaki fragments. Its growth is discontinuous.

2. DNA-ligase is required for joining Okazaki fragments.

3. The direction of growth of the lagging strand is 3′ -» 5′ though in each Okazaki fragment it is 5′ —> 3

4. Starting of each Okazaki fragment requires a new RNA.

5. Formation of lagging strand is slower.

6. Its template opens in 5′ —» 3’ direction.

7. Formation of lagging strand begins a bit later than that of leading strand.

Answer 2

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