ZuoTi.Pro
Question

2. Mutations that impact several regions of the Ras G protein and your own G protein can change the regulation of these G pro

science   biology   
0 0
Add a comment Improve this question Transcribed image text
Next > < Previous
Sort answers by oldest

Homework Answers

Answer #1

GAP protein is GTPase activating Protein which bind to G protein and help to deactivating the G protein by helping in hydrolysis of bound GTP and convert it to GDP. As a result G-protein became deactivated. If due to the mutation GAP cannot bind to activated G protein, then G protein remain in activated form (ATP bound form) and cannot be deactivated (ADP bound form) as bound GTP cannot be hydrolyzed to GDP by GAP protein. So the cell signalling which is mediated by G protein always remain turned on and the cell signalling mediated by G protein continues. This has deleterious effect in cell because the regulation that terminates G protein mediated signalling is lost.

0 0
Add a comment
Know the answer?
Add Answer to:
2. Mutations that impact several regions of the Ras G protein and your own G protein...
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Log In

Sign Up

Not the answer you're looking for? Ask your own homework help question. Our experts will answer your question WITHIN MINUTES for Free.
Similar Homework Help Questions

  • Ras is a proto-oncogene. A single mutation in the ras gene, resulting in a single amino...

    Ras is a proto-oncogene. A single mutation in the ras gene, resulting in a single amino acid change in the Ras protein, can significantly reduce the GTPase activity of Ras contributing to cellular transformation. a. How would a reduction in Ras GTPase activity effect signaling via an RTK pathway? Why? b. How might a gene therapy approach, in which a GAP protein is transfected into the transformed cell, be utilized in an attempt to rectify this situation?

  • 2. The following is a description of a signaling pathway initiated by receptor tyrosine kinases. Ligand → RTK → Sos → Ras → Raf → MEK → ERK → Transcription factor → Cell growth A. (3pts) Which of the...

    2. The following is a description of a signaling pathway initiated by receptor tyrosine kinases. Ligand → RTK → Sos → Ras → Raf → MEK → ERK → Transcription factor → Cell growth A. (3pts) Which of these steps indicates the protein is activated after a GTP exchange step? B. (3pts) Which of these proteins can be deactivated by phosphatases? C. (4pts) Describe a mutation that would cause Ras to be permanently "on"? Would this mutation lead to high...

  • please answer 1 a-f 1. Explain how G proteins are regulated. Include in your answer a...

    please answer 1 a-f 1. Explain how G proteins are regulated. Include in your answer a description of the functions of GTP binding, GTP hydrolysis, and GDP exchange for GTP in terms of effector activation, as well as the functions of regulatory proteins GEFs, GAPs, and GDls. (12 points total, 2 points each) A. Function of GTP and GDP binding on G protein activity B. Impact of GTP/GDP on G protein binding to an effector C. Role of G protein's...

  • 3. Mutations in bacteria that affect gene regulation may have a cis- or trans-effect on the...

    3. Mutations in bacteria that affect gene regulation may have a cis- or trans-effect on the expression of the protein-encoding genes in an operon? How would the following mutations affect the expression of the lac operon? Assume there could be more than one lac operon in the cell and that no glucose is present.   A. A mutation in the operator site that prevents the lac repressor from binding.   B. A mutation in the lacI gene that prevents allolactose from binding,...

  • The small monomeric G protein Ras is an important component of most receptor tyrosine kinase signaling...

    The small monomeric G protein Ras is an important component of most receptor tyrosine kinase signaling pathways. It can regulate a number of downstream signaling components, perhaps most famously the MAPK cascade. Unlike other monomeric G proteins that we have discussed previously in class, Ras is anchored at the plasma membrane by a covalently bound lipid anchor. If Ras was specifically mutated so that it did not get this lipid modification (but was otherwise completely unchanged), what do you hypothesize...

  • Classes 7-8 Cytoplasmic Growth Signaling Be able to describe Ras structure and function. What kind of...

    Classes 7-8 Cytoplasmic Growth Signaling Be able to describe Ras structure and function. What kind of protein is it? How is it regulated (Fig. 5.30)? How many forms of Ras do humans express? Be able to describe how Ras interacts with multiple downstream partners. What mechanisms render ras oncogenic? Also, how does Ras become oncogenic in the absence of ras mutations? Be able to describe how Ras interacts with the growth factor receptor signaling machinery. How did fly genetics help...

  • 14. You are studying a newly discovered growth factor. You find that this growth factor stimulates...

    14. You are studying a newly discovered growth factor. You find that this growth factor stimulates the proliferation of cells grown in the laboratory. You have also found that the receptor that binds the growth factor is a receptor kinase that activates Ras, which activates the MAP kinase pathway. Which mutations affecting this growth factor pathway would you expect to promote uncontrolled cell proliferation? Select all that apply. A. a mutation that inactivates the phosphatase that dephosphorylates the activated receptor...

  • There are several naturally occurring mutations in Hb. Some of the mutations are benign (harmless) while...

    There are several naturally occurring mutations in Hb. Some of the mutations are benign (harmless) while others cause serious health problems for the individuals who carry them. The table below lists two different Hb variants and the observed effects of the amino acid substitutions. Use this table and the illustration of the heme binding site to answer the questions that follow for one of the different Hb variants below. Mutation Name Mutation Consequence Hb Hammersmith F42 in B subunits Hb...

  • 4. The protein shown below is an enzyme-linked receptor. This means that this protein... Circle your...

    4. The protein shown below is an enzyme-linked receptor. This means that this protein... Circle your answer a) can speed up chemical reactions. b) can bind to certain signaling molecules. c) all of the above. D. Think about the enzyme-linked receptor we discussed in class. After the signaling molecules binds to this receptor, it causes the active site on the receptor to become available. What binds to this active site? E. Consider the molecule you named in the previous question....

  • Drosopholia eye development is an example of cell differentiation directed by signal binding to a receptor...

    Drosopholia eye development is an example of cell differentiation directed by signal binding to a receptor tyrosine kinase (RTK). In this pathway, R7 photoreceptor development requires a receptor (SEV, sevenless), which is activated by binding to a plasma membrane bound signal (BOSS, bride-of-sevenless) displayed on the adjacent R8 cell Receptor activation leads to activation of RAS via two proteins, Drk (down- stream of receptor kinases) and Sos (son-of-sevenless). Activated RAS leads to activation of a phosphorylation cascade that activates the...

ADVERTISEMENT
Free Homework Help App
Download From Google Play
Scan Your Homework
to Get Instant Free Answers
Need Online Homework Help?
Ask a Question
Get Answers For Free
Most questions answered within 3 hours.
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT