Individuals with a genetic defect in the ETC/oxidative phosphorylation are found to have relatively high concentrations...
Individuals with a genetic defect in the ETC/oxidative phosphorylation are found to have relatively high concentrations of alanine in their blood. Provide a reason for this in biochemical terms. Explain in detail by referencing pathways affected and intermediates that may be causing this effect.
Homework Answers
Because the ETC is not functional, the Krebs cycle intermediates which is malate will be converted into pyruvate and also the glycolysis will be ended in pyruvate and won't enter the Krebs cycle as the metabolites such as NADH and FADH produced in the Krebs cycle can't be utilized by the ETC. This is the reason why the pyruvate will be directed to producing more of alanine by the enzyme alanine transaminase and this is the reason why there is more of blood alanine.
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Individuals with a genetic defect in the ETC/oxidative
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