Question

2 points O In individuals with Sickle Cell Disease, only the adult form of hemoglobin carries a mutation in the myoglobin subunit. A potential therapeutic approach is to reactivate the expression of fetal myoglobin, which is normal and would reverse the disease. Which of the following steps is most likely to succeed in promoting transcription of fetal myoglobin in adult cells? Altering the expression of transcription factors to redirect the enhanceosome to the fetal gene promoter Removing the adult myoglobin promoter completely Adding a different RNA polymerase Adding a second locus control region (LCR) closer to the fetal gene

Answer 1

Ans-- D is the right answer.

Reason :- Local Control Region has a property of global regulation of gene expression over large distances and the role that modulation of chromatin structure plays in transcriptional regulation. Locus control region (LCR) regulates the transcription, chromatin structure.