In a case where we see a class of loss-of-function mutations and null alleles being produced....
In a case where we see a class of loss-of-function mutations and null alleles being produced. Can we assume its due to a mutant site on the promoter. Or a mutant site on an exon? As well for null alleles would transcript be detected on these sites and would we see a polypeptide form?
Homework Answers
Loss of function allele: A mutation
that abolishes the function of gene/protein
Null allele: A loss of function mutation that completely abolishes
the function of a gene/protein.
In a null allele,
a. The transcript may not be made due to mutations in the
promoter
b. The protein may not be made due to mutations in the ribosome
binding site/improper splicing/premature stop codons
A null can be produced if there is a nonsense mutation located
early in the coding sequence (Exon). In such a case, a truncated
protein is produced which does not exhibit any function.
A null allele may produce the transcript or protein. But, the
function is completely abolished.
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In a case where we see a class of loss-of-function mutations and
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