Question

Why are MHC molecules able to bind a variety of peptides?

Group of answer choices

A. the peptide-binding groove of a specific MHC molecule can bind several peptides simultaneously

B. The MHC genes undergo somatic recombination to produce thousands of MHC molecule variants

C. MHC bind very loosely and transiently to peptide antigens, so a wide variety of peptide antigens can bind any specific MHC molecule

D. a small number of amino acids in the peptide antigen bind specifically to complementary pockets in the MHC molecule binding groove

Answer 1

MHC molecules are able to bind a variety of peptides because : The MHC genes undergo somatic recombination to produce thousands of MHC molecule variants .

MHC molecules are coded by a polymorphic gene. This gene codes for cell surface protein major histocompatibility complex. MHC molecule on cell surface display a peptide or epitope . Which initiate the immune response against the pathogen. There are two class of MHC I and II. Class I MHC expressed in all nucleated cells, not in RBCs. Class II expressed in all cells,mainly in APC cells. Both of them represents epitope which can be recognized by other immune cells.