Question

Part A Explain why glucose consumption must increase in hypoxic tissues to provide the same amount of ATP that could be produced from glucose in normoxic (normal O, levels) tissues. et the eprivation mple, in for over reased the tect Jucible factor glycolytic alytic e starved reasing Bases. In hypox tissues, in contrast to normoxic tissues, ATP is additionally consumed to transform lactate to pyruvate Additional glucose is consumed by hipoxic tissues to be metabolized through the glyoxylate pathway In hypoxic tissues, ATP is produced only by glycolysis, whereas in normoxic tissues, the citric acid cycle + oxidative phosphorylation can be used. In hypoxic tissues, only the citric acid cycle is responsible for ATP production, whereas in normoxic tissues both glycolysis and oxidative phosphorylation are involved. athway, toplasmic chondrial - Submit Request Answer

Answer 1

Hypoxia is a condition where there is severe shortage of oxygen in the cells. Glycolysis is the only ATP-producing pathway that functions in both aerobic as well as anaerobic respiration. In contrast, citric acid cycle and oxidative phosphorylation also produce ATP but only in aerobically respiring cells. Therefore, a cell in hypoxic condition does not have oxygen, hence it cannot produce ATP via citric acid cycle or oxidative phosphorylation. It must keep the ATP at a steady level by consuming more glucose to keep glycosis going in order to fulfill the ATP requirement.

Hence, option (c) is correct.