Question

In the absence of infection ____________________ (Select all that apply).

Group of answer choices

A. MHC class II molecules bind to self peptides prematurely in the lumen of the endoplasmic reticulum

B. non-self peptides do not bind to MHC molecules

C. MHC class I and class II molecules bind to and transport self peptides to the cell surface

D. MHC class I and class II molecules are unable to progress through the vesicular system

Answer 1

Remember that the MHC complexes work for taking antigens from digested pathogens and display them in the cell surface so the immune system gets activated against such antigens. MHC class one are in charge of displaying self antigens to avoid the system to attack self cells, on the other hand MHC class II are only dedicated to pathogenic antigens, not cell antigens.

In the basence of infection MHC class I will keep displaying self antigens and no non-self antigen will bind to any MHC molecule.

The answer is option B. non-self peptides do not bind to MHC molecules (just because there are no non-self peptides)