Question

Nuclear receptors may be found:

a) In the milieu of the nucleus

b) In the cytosol

c) Bound to a response element in the nucleus

d) Both (a) and (b)

e) All of these

Answer 1

Ans. d) both (a) and (b)

Explanation:

There are two class of nuclear receptor:

Class I. Under this class, in the absence of ligand, nuclear receptor is located in the cytosol. ligand binding to the receptor triggers conformational changes and trnslocate to the nucleus.

Class II. This class of nuclear receptor, regardless of ligand binding status, is located in the nucleus bound to DNA.

Hence , the answer C is correct.