Question

At pharmaceutical companies the goal of many drug discovery experiments is to find improved drugs over existing drugs that bind to a target protein of interest. The graph below shows how "Drug A" binds to a target protein 1. Protein-Ligand Binding Curve for "Drug A" 1 0.9 0.8 0.7 0.6 Y 0.5 0.4 0.3 0.2 0.1 0 0 10 15 20 25 30 35 40 From the graph, estimate the Kd of "Drug A" for the target protein. Report the Kd in units of M (mol/L) a) Using an equation and the information from part a, now calculate the fraction of protein bound (Y) for "Drug A" when [L] = 55 μM b)

Answer 1

0.3ジーナ10 8=6,2 L 2=0,8 L 는. 55 91 , 66 :/. 는 D) ONSA DNSA O.S Kooft 는 5 kolf= 10 475ha kd → Lowe, Afhhib