Question

___will bind the Na+/K+ pump when it is in the open-in (E1) configuration

2 Na+ ions

3 Na+ ions

2 K+ ions

3 K+ ions

ATP

Answer 1

Ans:

In conformation E1, three sodium ions bind to the pump from the cytoplasmic side of the phospholipid bilayer membrane.

Explination for Sodium-Potassium Pump

The sodium-potassium pump, also known as Na,K-ATPase, which is a member of the P-type class of ATPases, it is a critical protein found in the membranes of all animal cells. The function of the protein is active transport of sodium and potassium ions across the cell membrane against their concentration gradients .

Purple Balls = Sodium Ions

Blue Balls =Potassium Ions

1. In conformation E1, three sodium ions bind to the pump from the cytoplasmic side of the phospholipid bilayer membrane.

2. ATP phosphorylates the enzyme, as indicated by the P attached to the cytoplasmic side of the pump, and the remaining ADP is released.

3. The conformation then changes to E2, and the three sodium ions are released into the extracellular space.

4. Two potassium ions bind to the pump from the extracellular side.

5. The pump is dephosphorylated and returns to conformation E1.

6. ATP binding occurs and the potassium is released into the cytoplasm.