Immunophenotyping is performed on a patient suspected of having PNH. What monoclonal antibody specificity should be...
Immunophenotyping is performed on a patient suspected of having PNH. What monoclonal antibody specificity should be ordered?
a.) CD33 and CD13
b.) CD56 and CD4
c.) CD3 and CD8
d.) CD55 and CD59
Homework Answers
ANSWER - ( D ) CD55 and CD59
REASON-
PNH aka (PAROXYSMAL NOCTURNAL HAEMOGLOBINURIA ) is a lethal disease that is characterised by destruction of RBCs (haemolytic anemia) or by aplastic anemia.
Immunophenotyping is a technique to identify specific antigens expressed by cells by the use of antibodies . It is useful in diagnosis and classification of haemotological malignancy
CD55 AND CD59 are surface the surface proteins present on RBCs and granulocytes that help in inhibiting C3 convertase . In patient with PNH the CD55 AND CD 59 undergo impaired conformation leading to excessive destruction of RBCs and leukocytes.
* Hence the CD55 AND CD59 monoclonal antibody should be ordered to diagnose PNH .
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