Question

1) Draw a diagram of a bacterial replication fork showing the leading and lagging strand of new DNA and the enzymes responsible for the processes involved. Indicate the 3' and 5' end of each nucleic acid strand.

2) The ends of a linear chromosome cannot be replicated by the normal DNA replication enzymes. Why? How does the eukaryotic cell solve this problem?

Answer 1

1). Here is the Bacterial replication pic with labeling all the enzymes and astrands orientation.

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2). Ends of Ek chromosome do not replicate due to primer excision leave the gap and these will form 5' overhangs so these are seved by exonucleases later leads to shortening of chromosomes. To prevent this cell has regulatory mechanism and enzymes helpls iin this process are Telomerases. Conventional DNA pols need template to add nt to new strand but Telomerase is not , it has its own template (Ribonucleotides.) and add nts to ends and seal them to protect.

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