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A) Microtubule motor proteins contribute to the assembly and overall length of the mitotic spindle. Using...
5A. (6pts) Please describe how microtubule dynamics play a role both in the assembly of the mitotic spindle during metaphase and the segregation of chromosomes during anaphase. B. (6pts) Nocodazole is a microtubule depolymerizing drug, and is often used to synchronize populations of cells so that they are in the same point in the cell cycle. Please describe how the molecular effect of nocodazole leads to cell synchronization. B. (6pts) You isolate mutant cells defective in the DNA-damage checkpoint, but...
2. A dominant allele H reduces the number of body bristles that Drosophila flies have, giving rise to a “hairless” phenotype. In the homozygous condition, H is lethal. An independently assorting dominant allele S has no effect on bristle number except in the presence of H, in which case a single dose of S suppresses the hairless phenotype, thus restoring the "hairy" phenotype. However, S also is lethal in the homozygous (S/S) condition. What ratio of hairy to hairless flies...