A strain of mice
A strain of mice
Homework Answers
1. These results can be explained as follows:
The ratio of short tailed mice and normal tailed mice is around 2:1. This ratio is typical for a lethal gene. This means that the mutation for short tail results in a lethal allele. Considering the dominant allele A and recessive allele a. We can say that aa is lethal and the offspring does not survive. Whereas, in Aa condition mice survive but they possess a short tail. This means that short tailed mice will have Aa genotype while normal tailed mice will have AA genotype. Offsprings with aa genotype will be eliminated.
2. The expected phenotype for mice in this population will be:
AA- normal- tailed offspring
Aa- short-tailed offspring
aa- Offspring that won't survive.
Two experimental groups of the same genetic strain of mice are being used for toxicological experiments....
Two experimental groups of the same genetic strain of mice are being used for toxicological experiments. Each group of mice is administered the same single oral dose of a xenobiotic and monitored for acute lethality. After 4 days, all of the mice in one group are dead and all of the mice in the other group are alive. Provide six explanations for the difference in susceptibility of these two groups of mice. (2 marks each, 12 marks total) 4. a)...
TAC and JAX are two different strain of mice. Both were injected with melanoma (cancer) cells...
TAC and JAX are two different strain of mice. Both were injected with melanoma (cancer) cells and the growth of tumors in the animals was monitored for several days. With respect to the following figure: What are the results? . 1500 -a-TAC ㅎ. JAX What do the results tell you about the two mouse strains? . 500 7 10 13 16 20 22 Day post injection In another experiment, TAC mice were co-housed with JAX mice for three weeks. During...
I need help with this question below. Researchers generated a transgenic strain of mice called DrpTg...
I need help with this question below. Researchers generated a
transgenic strain of mice called DrpTg which overexpresses a
protein called Drp1 under a muscle-specific promoter. DrpTg mice
had poor postnatal weight gain, smaller muscle mass and lower
muscle strength than WT mice of the same age and fed the same diet.
The experiments shown in the left panel below showed that
phosphorylation of the normal cellular protein labeled P-? was
increased in DrpTG muscle compared to WT muscle tissue....
The following groups of mice are exposed to a pathogenic bacterium. Luckily for these mice, this...
The following groups of mice are exposed to a pathogenic bacterium. Luckily for these mice, this pathogen can be removed by activation of the classical complement cascade. Match the mouse strain with its appropriate treatment against this bacterium. Note: each answer choice may be used more than once, but not all answer choices will be used. 1) IL-12 or IFN-γ 2) Anti-IFN-γ antibody 3) IL-4 4) Anti-IL-4 antibody 5) Lymphocytes from a previously infected mouse 6) No additional treatment necessary...
Use the table to answer the question. In 1928, Frederick Griffith injected four groups of mice...
Use the table to answer the question. In 1928, Frederick Griffith injected four groups of mice with different strains of the bacteria, Streptococcus pneumoniae. The smooth strain had a polysaccharide capsule that protected the bacteria from the mouse's immune system. The rough strain did not have this capsule. The details of each group and the results of the experiment are shown in the table below. Bacteria After injection with bacteria Group 1 smooth strain mice died Group 2 rough strain...
4. p53 is an important cancer suppressor gene. To study its function, it is very useful to have p53 knock-out mice. How can one best prepare a strain of p53 knock-out mice? Please start with the optim...
4. p53 is an important cancer suppressor gene. To study its function, it is very useful to have p53 knock-out mice. How can one best prepare a strain of p53 knock-out mice? Please start with the optimal method to introduce mutations into DNA, and then describe how you would incorporate such DNA into the mouse genome. List all major steps. please give detailed answer, thank you!
You have generated three different strains of mice each strain completely missing the complement protein indicated...
You have generated three different strains of mice each strain completely missing the complement protein indicated in the table below, Predict the effect of each missing protein on the event indicated in the 1 column of the table. Fill in the table (each box labeled 1-9) with one of the following symbols: (12 pts.) NE = no effect on the event because none of the complement pathways are blocked D = event will be decreased. but not eliminated because some,...
You are studying hyperactivity in mice. You know that this phenotype is dominant and is determined...
You are studying hyperactivity in mice. You know that this phenotype is dominant and is determined by just one gene (H) but you need to discriminate between the following alternatives: mitochondrial inheritance, maternal effect, regular nuclear inheritance. You cross female mice from a true-breeding hyperactive strain to males from a true-breeding super-chill strain. All the F_1 progeny is hyperactive. Can you at this point eliminate any of the three modes of inheritance? You cross these hyper F_1 mice to each...
3. A cancer laboratory is estimating the rate of tumorigenesis in two strains of mice, A...
3. A cancer laboratory is estimating the rate of tumorigenesis in two strains of mice, A and B. They have tumor counts for 10 mice in strain A and 13 mice in strain B. Type A mice have been well studied, and information from other laboratories suggests that type A mice have tumor counts that are approximately Poisson-distributed with mean 12. Tumor count rates for type B mice are unknown, but type B mice are related to type A mice....
7. In mice the coat color called agouti results from a dominant allele A. Mice that...
7. In mice the coat color called agouti results from a dominant allele A. Mice that are AA or Aa have agouti fur. Mice that are aa have black fur. However to get any coat color at all, at least one copy of a second dominant allele C of a different locus must be present. If a mouse has genotype cc, the mouse is albino regardless of what is happening at the other gene pair. Suppose two mice with genotypes...
Two experimental groups of the same genetic strain of mice are being used for toxicological experiments. Each group of mice is administered the same single oral dose of a xenobiotic and monitored for acute lethality. After 4 days, all of the mice in one group are dead and all of the mice in the other group are alive. Provide six explanations for the difference in susceptibility of these two groups of mice. (2 marks each, 12 marks total) 4. a)...
TAC and JAX are two different strain of mice. Both were injected with melanoma (cancer) cells and the growth of tumors in the animals was monitored for several days. With respect to the following figure: What are the results? . 1500 -a-TAC ㅎ. JAX What do the results tell you about the two mouse strains? . 500 7 10 13 16 20 22 Day post injection In another experiment, TAC mice were co-housed with JAX mice for three weeks. During...
I need help with this question below. Researchers generated a
transgenic strain of mice called DrpTg which overexpresses a
protein called Drp1 under a muscle-specific promoter. DrpTg mice
had poor postnatal weight gain, smaller muscle mass and lower
muscle strength than WT mice of the same age and fed the same diet.
The experiments shown in the left panel below showed that
phosphorylation of the normal cellular protein labeled P-? was
increased in DrpTG muscle compared to WT muscle tissue....
Use the table to answer the question. In 1928, Frederick Griffith injected four groups of mice with different strains of the bacteria, Streptococcus pneumoniae. The smooth strain had a polysaccharide capsule that protected the bacteria from the mouse's immune system. The rough strain did not have this capsule. The details of each group and the results of the experiment are shown in the table below. Bacteria After injection with bacteria Group 1 smooth strain mice died Group 2 rough strain...
You have generated three different strains of mice each strain completely missing the complement protein indicated in the table below, Predict the effect of each missing protein on the event indicated in the 1 column of the table. Fill in the table (each box labeled 1-9) with one of the following symbols: (12 pts.) NE = no effect on the event because none of the complement pathways are blocked D = event will be decreased. but not eliminated because some,...
You are studying hyperactivity in mice. You know that this phenotype is dominant and is determined by just one gene (H) but you need to discriminate between the following alternatives: mitochondrial inheritance, maternal effect, regular nuclear inheritance. You cross female mice from a true-breeding hyperactive strain to males from a true-breeding super-chill strain. All the F_1 progeny is hyperactive. Can you at this point eliminate any of the three modes of inheritance? You cross these hyper F_1 mice to each...
3. A cancer laboratory is estimating the rate of tumorigenesis in two strains of mice, A and B. They have tumor counts for 10 mice in strain A and 13 mice in strain B. Type A mice have been well studied, and information from other laboratories suggests that type A mice have tumor counts that are approximately Poisson-distributed with mean 12. Tumor count rates for type B mice are unknown, but type B mice are related to type A mice....
7. In mice the coat color called agouti results from a dominant allele A. Mice that are AA or Aa have agouti fur. Mice that are aa have black fur. However to get any coat color at all, at least one copy of a second dominant allele C of a different locus must be present. If a mouse has genotype cc, the mouse is albino regardless of what is happening at the other gene pair. Suppose two mice with genotypes...
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