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Indicate which of the amino acid residues in the following peptide sequence contains a group that...

Indicate which of the amino acid residues in the following peptide sequence contains a group that has a negative charge for its most likely charge state at pH 10.

Glu-Cys-Tyr-Lys-Asp-Ile-Leu-His-Trp

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Answer #1

In this Glutamic acid( Glu) and Aspartic acid contain carboxylic side chain that having pKa around 4-5. At this pH these carboxylic acid will lose their proton and present at their carboxylate form hence, here glu and aps will contain negative charge. If you have to choose one amino acid than Asp is more correct because glu also contain amino group and that loose the proton slightly above or near to 10 hence this amino acid is having both charges positive and negative and it may make salt bridge.

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