"? N H Cbz N H Cbz Cl Cl J.Org. Chem. 2001, 66, 4625-4629. PhyP ????2(t-Bu)...
Cl H2 Pt Cl 1. LAH OH 2. H,0 H2 Pt + H,N
Assign R or S
RO "B" "C" "A" O RO t-Bu. CH3 hv HOS N- t-Bu Ts cat. HO• t-Bu N-Ts RO SO HO N-TS RO SO RO SO
mechanism please!
2). i) KOt-Ви Me Me ії) А, о H t-Bu А. о он о t-Bu" Me Me Me t-Bu Me В. D. ОН о Ме. t-Bu. Me t-Bu Me Me
Describe the relationship between the following two molecules: Н t-Bu t-Bu. H Et Et Constitutional isomers Enantiomers Diastereomers Conformational isomers Identical molecules Submit Answer Tries 0/1 Describe the relationship between the following two molecules: Br H н Br Diastereomers Identical molecules Enantiomers Constitutional isomers Conformational isomers Submit Answer Tries 0/1
Determine the major product for each reaction.
mCBPA NaSH DMF NaOt-Bu t-BUOH DBT peroxides, hv Cl(equivi SOCI Pyr Tsal pyr DMP O 2 HD workUp 1. LiAID 2. M30+ workup
REVIEW SHEET FOR E2 IN CHEM 3153, OCTOBER 27, 2019 Draw the structure for the MAJOR ORGANIC PRODUCT form each reaction. Assume the reactions have been terminated and neutralized. a. R-COR + DIBAL-H in hexane/-78 'C ------------ OR 1. CO2 b. Ph-Br + Mg/ether - -> 2. H,0* THE c. methyl butanoate + LDA -----> H.C-1 HO* H30* (cat) d. acetone + 2,4 (ON),C,Hy-NH-NH2 cyclohexanone e. PhyP-CH, I + PhLi/ether -- > H20 f. H.C-CH2-CH2-COH + BryP ------> -- n-Bu-Br...
5) a) Because of the presence of three very bulky tert-butyl groups (t-Bu) both coumpounds 1 and 2 exist as a single conformer. Draw the only existing conformer for 1 and 2 Br OH t-Bu **74-Bu t-Bu 1 OH -Bu Bu b) Which of these two isomers 10 2 leads to the formation of an epoxide when reacted with NaOH ? Draw the structure of the resulting epoxide 3 showing the stereochemistry. NaOH
1. Cl, H20 2. NaOH 3. CH3CH2MgBr 4. H30* 1. Mg 2h) 2. H₃C.. 3. H30+ 1. SOCI OH 2. DIBAL"H 3. H30* OH 1. NaOH 2j) 2. CH3CH2CI 3. O o 2k) [ N-H H20. STAB OH 2)) 1. NaOH 2. CH3CH,CI 3. O o IN-H 2k) H30*. STAB 21) 1. 2 KCN, HCN 2. LiAlH4 3. H30+ 4. H2, Pt
H,N. Py H,N. H,N ,C Cl P1 H,N H,N NH H2 NH, H, Compounds A-D are anti-cancer drugs in curren! cⅢical use or under investigation in trials. () Assign oxidation states to all of the platinum ions in molecules A-D (3 marks) () Describe the similar mechanism of action for compounds A-C accounting for any differences. Rationalise the data below in terms of providing effective cancer treatment. Cytotoxicity (CCso in vitro) Maximum tolerated dose 2.3 uM 200 mg m2 51.6...
Cl Cl 1. PhMgBr (2 mols) Cl 2. H30. ?? 2. H,O HO-1