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Connections between the ECM and cytoskeleton, specifically the dystrophin- glycoprotein, are defective in muscular dystrophy.
Examples of extracellular matrix proteins include all of the following EAUEPI? Select one: a. Perlecan b. Laminin c. Collagen
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Answer #1

1.True-

Dystrophin is a rod-shaped cytoplasmic protein, and a vital part of a protein complex that connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane .

Muscular dystrophy is caused by genetic mutations that interfere with the production of muscle proteins that are needed to build and maintain healthy muscles. It is caused by mutations in the DMD gene, resulting in deficiency or absence of functional dystrophin

2.Perlecan

Perlecan is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix (ECM) components and cell-surface molecules.

All others Laminin,collagen,Integrin are ECM proteins.

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