NH2 8. Show how the following transformation can be accomplished. (12 pts)
3. Give the reagents necessary to complete the following transformation. Hint: It can be accomplished in one step. (3 pts.) Br 4. Circle which reaction in the following reaction pairs you would expect to be faster. You do not need to give the products. (2 pts, each) Br + CH,OH methanol . . -Br . chou + CH.OH methanol methanol + NaCl ethanol + NaBr ethanol
4. The transformation of the alkyl chloride shown below into the alcohol can be accomplished in two steps. Show the synthetic scheme to finish the conversion. (I point) ОН
4. The transformation of the alkyl chloride shown below into the alcohol can be accomplished in two steps. Show the synthetic scheme to finish the conversion. (1 point) OH
The following transformation can be easily accomplished under either of the conditions shown. Provide a complete arrow-pushing mechanism for each of these methods to accomplish the transformation (10 points total, 5 points each mechanism). NaOH ОН ОН
Predict the product for the following transformation. Predict the reagent for the following transformation. NH2 1. Ac, 2. t-BuCI, AICI: 3. KOH, H2O 4. NaNO2, HCI 5. Cuci Me (4 pts) Predict the product for the following transformation. Me Me Me Me NH Me Me
CH30 CHEQ How can the following transformation be accomplished? ? CH2CH OH 18a A. Mg B. Bry/FeBr3 C. HNO3/A E. 2(Hg)-HCI F. H2SOJA G. NaOH/H20 I. CH3CH2CHO J. CH3CH2Li K. Cul L. N. H30 0. Cly/FeCl3 P. &CH D. CH3-C-ci /AlCl3 H. NaBH4/CH3OH CH2-CHLI M. H a) M and F then N d) D then J then N b) A then I then F e) I then H c) B then A then I then N
9. Devise a multistep synthesis for the following transformation. Show all intermediates and reagents. NH2 Br ???
For each of the transformations below, provide the reagents necessary. Each transformation can be accomplished in 4 or fewer steps. Be sure to indicate stereochemistry where relevant!
please explain How can this transformation be accomplished? OTS ?, A. Bry/CCI: B. H./Pd-C c. O/CHOH D. Br /HO H.B-H G. H.0 /acid I. H.O/NaOH F.H.O E. Zn K. NaH J. CI/H0 L. mCPBA M. H.SOJA N. TsCl/py 0. KMnO/KOH [A] H then M P. NaOH [B] D Q. HO/H.SO [C] O [D] P then B [E] K Explanation for your choice (3 pts)
1. (2 pts) Predict the product for the following transformation. NH2 1. Ac 0 2. t-BUCI, AICI: 3. KOH, H2O 4. NaNO2, HCI 5. Cuci Me