Question

I will rate it with thumbs up if you answer both the question with brief explanation.

1. What effect will a mutation in a mismatch repair gene (e.g Msh2) have on gene conversions and crossing over in A) heterozygous organism B) Homozygous organism?

2.How do PARP inhibitors work in cancer therapy ?

Answer 1

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I have very less knowledge about question no1. So i am writng answer no2

Answer-)

PARP inhibitors are the type of targeted cancer drug. Poly-ADP ribose polymerase (PARP) is a protein found in cells. It helps damaged cells to repair themselves. As in cancer treatment, PARP inhibitors stop the PARP from repairing cancer cells and cell dies. Olaparib is a type of PARP inhibitor for women with ovarian cancer, fallopian cancer, peritoneal cancer. Researchers found that PARP inhibitors may be particularly effective against cancers in people with inherited mutations, that includes BRCA and PALB2.