Question

1. why might a protein have multiple domains. 2.why a protein might be comprised of more than one chain. 3.why a protein structure might show gaps when the real protein has none. 4.why a protein might bind nucleic acids. 5.why a protein might have disulfide bonds. 6. are ligands important for function or just artifacts of the structure process? 7. Why would the surface of a membrane-bound protein have a different polarity from a soluble one?

Answer 1

1) proteins have diffrent domains to exhibit multiple functionality.side chains are critical to protein structure because they can bond with one another to hold a length of protein in a certain shape or conformation.The dna binding proteins have affinity to single or double stranded dna.Sequence-specific DNA-binding proteins generally interact with the major groove of B-DNA, because it exposes more functional groups that identify a base pair.

The disulfide bonds are strong, with a typical bond dissociation energy of 60 kcal/mole (251 kJ mol⁻¹). However, being about 40% weaker than C–C and C–H bonds, the disulfide bond is often the "weak link" in many molecules.