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If a woman who is a carrier for sickle-cell anemia marries a man who is not...

If a woman who is a carrier for sickle-cell anemia marries a man who is not a carrier, would any of their children get sickle-cell anemia? (Not sex-linked!) Prove it by doing a Punnett Square using the correct genotypes.

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Answer #1

Normal allele: S, sickel cell anemia allele: s

Carrier woman: Ss, normal person: SS

Parents: carrier woman. X. Normal person

Genotype: .Ss. SS

Gamete: . S/ s. S

Gamete S
S

SS

Normal

50%

s

Ss

Carrier

50%

50% progeny are normal and 50% progeny are carrier.

As result the 100% offsprings have normal phenotype with 50% carrier offspring.

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