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The [PSI+] prion is pretty weird and obscure. Can you give a more general example?

The [PSI+] prion is pretty weird and obscure. Can you give a more general example?

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Answer #1

The most famous example is loss of function of the chaperone Hsp90 . Hsp90 stabilizes many metastable signal transducers. When an organism is in trouble, Hsp90 may have too much work to do, mimicking a partial deletion. This has unpredictable consequences, depending on which cryptic variants are present in that individual

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Answer #2

Prions in simple words can be understood as infectious proteins.It has four helix PrPc

One example that can be considered is chaperone Hsp90. It tabilize many transducers. It can mimic a partial deletion and can cause destabilization of the proteins.

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