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Marfan syndrome is an autosomal dominant disorder that results in the overgrowth of long bones of the body. The causative gene, fibrillin-1, has been mapped to the q arm of chromosome 15, an acrocentric chromosome (normal allele: f; syndrome allele: F). An individual affected with Marfan syndrome has a heterozygous genotype.

Q 1 . Which of the images below depicts the correct allele configuration immediately following S-phase of the cell cycle in this individual?

f

A. 1

B.2

C. 3

D. 4

Q 2. Which of the images above depicts the correct allele configuration following Prophase I of Meiosis I?

A. 2

B. 3

C. 2 OR 3 ARE BOTH POSSIBILITIES

D. 4

Second part is the same image as the first one

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Answer #1

1. 2

Heterozygous genotype means there will be two different alleles on both the chromosomes. One of the chromosome will have F and the other will have f. The two sister chromatids of the chromosome will have same alleles.

2. 2

Reason described in 1.

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