Question

The following image shows the 20 amino acids found in proteins. OH CH H HNCOOH Glycine HN HẠN CHO Alanine HẠN COOH Serine н соон Threonine Cysteine HAN COOHHN COOH Nлсоон н соон Methionine Valine Leucine Isoleucine Proline OOH MNCOOHHN COOH HN COOH H COOH HẠNỐIOOH Apartic Acid Phenylalanine Tyrosine Tryptophan Glutamic Acid HNCOOHH COOH Asparagine Glutamine HNCOOHNCOOH Histidine Lysine н соон Arginine Imagine that in a protein, a lysine amino acid is replaced with an isoleucine. What is the most likely consequence of this change in the protein's primary sequence? O A. The shape of the protein would change, but the function would not be affected. O B. This is a conservative change - the shape and function of the protein would most likely not be affected. C. This is a non-conservative change - the change is restricted to the primary structure only; since the tertiary structure isn't affected we do not expect it to impact the function of the protein. OD. This is a non-conservative change - the change in amino acid would change the bonds in the tertiary structure of the protein, and therefore potentially change its shape or active site. UE. The change in amino acid would affect the secondary structure of the protein.

Please explain, Thanks!

Answer 1

Answer - option D

This is a nonconservative change because lysine (a positive charge and polar amino acid) is replaced by the isoleucine (nonpolar and uncharged amino acid), this results in a change in the physicochemical properties, would affect the interaction in the tertiary structure of the protein. The change in the structure or shape of the protein would affect the function of the protein.