Aneuploidy is both beneficial and detrimental.
Demerits of aneuploidy:-
Causes sterility in crosses.
Affected individuals cannot be used further as a parent in hybridization.
Imbalance in gene expression leads to deformities in phenotype like down's syndrome,klinfelter's syndrome,t urners syndrome.
Benefits of Aneuploidy:-
Genetic alterations can help in cancer treatement.
Alterations in proteosomal degradation system can help in studying and exploring evolution of tumors.
Aneuploidy affects gene expression at a proteome level and transcriptome level and generate significant phenotypic variation that can lead to fitness gain.
What are the usual consequences of aneuploidy and is it usually beneficial or detrimental? Why is...
Aneuploidy has a detrimental effect on phenotype because Aneuploidy has a detrimental effect on phenotype because Check All That Apply eukaryotic chromosomes carry hundreds or even thousands of genes. o incorrect dosage of genes from one chromosome puts the proportions of gene products out of balance. incorect dosage extra dosage of genes from all the chromosomes overwhelms the cell with protein. the cell has a mechanism to count chromosomes and self-destruct in case of error.
How is aneuploidy different from polyplodidy ?What are the mechanisms by which aneuploidy and polypeptide are caused,and what are the consequences of these chromosomes alterations in terms of survival and fertility of the offspring?
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Explain how nondisjunction generates aneuploidy. Describe the most common aneuploidy conditions. Given what you know about the X and Y chromosomes, why does YO not exist?
Aneuploidy of an autosome is always more harmful than an aneuploidy of a sex chromosome. One of the explanations as to why sex-chromosome aneuploids are less harmful is due to X inactivation. X-inactivation assures that all human cells only express a single X chromosome regardless of how many X chromosomes are present. Interestingly, sex chromosome aneuploids (i.e. XXY, XO) still have some different phenotypes compared to either an XX or XY individual. For instance, XXY individuals (Klinefelter Syndrome) are taller, have...
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What are the potential consequences of un-repaired DNA damage (i.e. mutations) (select all that apply)? A. Mutations are always detrimental B. Mutations are always beneficial OC. Somatic mutations lead to cancer or other disease in the affected individual ONLY D. Germ line mutations lead to cancer or other disease in the affected individual ONLY E. Germ line mutations lead to changes in fitness for the affected individual ONLY OF. Somatic mutations lead to changes in fitness for the progeny OG....