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What are the usual consequences of aneuploidy and is it usually beneficial or detrimental? Why is...

What are the usual consequences of aneuploidy and is it usually beneficial or detrimental? Why is it beneficial/detrimental?
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Answer #1

Aneuploidy is both beneficial and detrimental.

Demerits of aneuploidy:-

Causes sterility in crosses.

Affected individuals cannot be used further as a parent in hybridization.

Imbalance in gene expression leads to deformities in phenotype like down's syndrome,klinfelter's syndrome,t urners syndrome.

Benefits of Aneuploidy:-

Genetic alterations can help in cancer treatement.

Alterations in proteosomal degradation system can help in studying and exploring evolution of tumors.

Aneuploidy affects gene expression at a proteome level and transcriptome level and generate significant phenotypic variation that can lead to fitness gain.

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