Question

Aneuploidy has a detrimental effect on phenotype because

Aneuploidy has a detrimental effect on phenotype because Check All That Apply eukaryotic chromosomes carry hundreds or even thousands of genes. o incorrect dosage of genes from one chromosome puts the proportions of gene products out of balance. incorect dosage extra dosage of genes from all the chromosomes overwhelms the cell with protein. the cell has a mechanism to count chromosomes and self-destruct in case of error.

Answer 1

Aneuploidy is a category of chromosomal mutation in which cells have abnormal chromosome number, either their is loss or gain of chromosomes. These can be trisomic (when there is one extra chromosome i.e 2n+1), monosomic ( when there is one less chromosome i.e 2n-1) and nullsomic ( when 2 chromosomes are less 2n-2). Although cell has mechanisms and checkpoints so that chromosome segregation occur accurately still sometimes there is error occurs and aneuploidy will take place.

Aneuploidy mostly has deterimental effect on phenotype of individual. This occurs because as number of chromosomes changes so their will be different quantity of DNA than normal individual. So their is a change in gene dosage. If their is trisomy means their is increase in gene dosage and if their is monosomy means decrease in gene dosage. So this change in gene dosage lead to imbalance in corresponding gene products i.e proteins coded by them. This will lead to abnormal phenotype which is mostly detrimental. This will lead to diseases as in Down Syndrome which is a trisomic condition of chromosome 21 leading to mental retardness and developmental delay.

So the " incorrect dosage of genes from chromosomes puts the proportions of gene products out of balance" is right choice of this question.

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