Question

THE TOPIC IS DNA & GENETICS Create a annotated Bib+ including the following

Relevance to subject: how does this article support your topic(toipic DNA and genetics)? Importance of author in the field: find out how many times this article/book has been cited. Include any other important information you discover about the author--try a Google search on him or her! • An in-text citation example included in summary: use a quotation from the article in your summary and cite it correctly. • Paraphrasing example: Include a few sentences in quotation marks, properly cited, and then paraphrase those sentences directly below the quotation also properly cited (like you were including the paraphrase in a paper). This should be separate from the summary.

The article is

IsK and KvLQT1: mutation in either of the two subunits of the slow component of the delayed rectifier potassium channel can cause Jervell and Lange-Nielsen syndrome.

https://www.ncbi.nlm.nih.gov/pubmed/9328483

Answer 1

Summary

"The Jervell and Lange-Nielsen syndrome (JLNS) comprises profound congenital sensorineural deafness associated with syncopal episodes.  locus: five families of differing ethnic backgrounds were homozygous by descent for markers close to the KVLQT1 gene and a further three families from the same geographical region were shown to be homozygous for a common haplotype and to have the same homozygous mutation of the KVLQT1 gene. However, analysis of a single small consanguineous family excluded linkage to the KVLQT1 gene, establishing genetic heterogeneity in JLNS." In this research work, the author has analysed mutations at a particular gene loci. The results had been consistent as they were confirmed using five different families of different ethnicities , KVLQT1 gene was found to have the mutation, with genetic heterogeneity in the same disease as one of the families did not have show mutation in the KVLQT1 gene.

The article is in complete relevance with the given topic I.e. DNA and genetics. This author talks about a mutation- mutation is the alteration of the nucleotide sequence in the genome in an organism , thus it is completely relevant to DNA and genetics.

This article has been cited 41 times by pubMed central articles and a total of 301 other articles. The author Jessica Tyson, is a member of Units of Clinical and Molecular Genetics, Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, UCL Medical School, 30 Guilford Street, London WC1N 1EH, UK.