Sickle cell anemia is an autosomal recessive disorder. The blood group of person having this disease will be HbSHbS.
So, if a child has this blood group, it means that both of his parents are carriers, with the blood group HbSHbA.
So, the cross was HbSHbA X HbSHbA
The normal children will have blood group HbAHbA. Note that chances of having normal: affected children are 3:1.
This further implies that one of the parents of the wife and husband are also carriers of the disease.
Parents of the wife and husband have the genotype: HbSHbA X HbAHbA i.e. one parent is normal and the other is a carrier. The result of the above cross will be:
1(HbAHbA normal) : 2 (HbSHbA, carriers) : 1 (HbSHbS, affected). Note that chances of having a carrier child are 50% or ½, and chances of having an affected child from the carrier are ¼ or 25%.
So, if the sister of the husband marries the brother of the wife, the probability of their first child having sickle cell anemia = (chances of being a carrier * chances of having an affected child from the carriers) = ½ * ¼ = 1/8 (12.5%).
A couple of normal ancestry has two normal children and an infant affected with sickle cell...
A woman has a father with sickle-cell anemia, which is an autosomal recessive trait. She does not have symptoms of sickle-cell anemia. What is her genotype? (0.5 marks) b) She is about to start a family, and she knows that her partner’s mother has sickle-cell anemia, but he does not have the disease himself. What is the probability of them having a child with sickle-cell anemia? Demonstrate this using a Punnett square. (2.5 marks) c) If they have three children,...
Problem on genetics, Please solve for what is asking for
the first and the second pedigree, I have included every single
detail that is helpful to the problem
Antoine’s narrative:
I have a sister who has sickle cell disease. She is not married.
Neither my mom nor my dad has the disease. My mother has two
brothers and one sister, although one of her brothers passed away
when I was very young from complications of sickle cell anemia.
Neither my...
A man who is “normal” (has no sickle cell allele) has children with a woman who is immune to malaria. What percentage of their children would also be immune to malaria? What percentage would have sickle cell disease? Show a Punnett square using the genotypes/alleles.
Use the following information to answer the next two questions. Sickle cell anemia is a disease that is caused by a mutation in the gene that produces haemoglobin. Hemoglobin carries oxygen in red blood cells. The HbA allele produces normal hemoglobin and the HbS allele produces haemoglobin that sticks together and causes red blood cells to sickle. Heterozygous individuals (HbAHbS) produce both normal and "sickle" hemoglobin so the HbA and HbS alleles are codominant. Heterozygotes do not develop sickle cell...
A couple has two children and the oldest child is a boy. If the probabilities of having a boy or girl are both equal what is the probability that the couple has 2 boys
QUESTION 60 0.33334 points (E "Sickle cell anemia is produced by a genetic defect in the amino acid sequence of hemoglobin. Persons who are homozygous for this allele have abnormal red blood cells, which characterize the disease. The blood cells of heterozygous persons appear normal and they are considered carriers. A test reveals that a man is heterozygous for the sickle cell allele but his wife is homozygous normal. What is the probability of their children will be carriers of...
Sickle Cell Case Study Read the following case study and answer the questions below. Provide evidence with correct citations to support your answers. V.M. is a 29 year old African American married man who has sickle cell disease (SCD) marked by frequent episodes of severe pain. His anemia has been managed with multiple transfusions. Six months ago he started showing signs of chronic renal failure. His regular medications are pentoxifylline (Trental), oxycodone-acetaminophen (Percocet), hydroxyurea (Droxia), and folic acid. In the...
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Question 2:
You are a population geneticist interest in the frequency of the sickle-cell allele in a small town in Sudan. From hospital records you know that people in the previous generation had 4% incidence of sickle-cell anemia. Assuming Hardy-Weinberg equilibrium, what is the expected frequency of the sickle-cell allele in the current generation, and what is the predicted frequency of heterozygotes in the population? Consider a woman who suffers from Menkes Disease, an X-linked recessive disease. Her...
Suppose that you are studying is a rare recessive condition in humans whereby affected individuals are unable to metabolize a sugar found in certain foods. A woman and her husband are both heterozygous for the allele causing the condition. A) If the woman is pregnant with twins and the twins are dizygotic (non-identical), what is the probability that both twins will be girls and be affected? B) What is the probability if the girl twins are identical (monozygotic) and both...
Two parents come to see you for genetic counseling. Dad is sickle cell carrier (sickle cell is a recessive genetic disease) and has a normal cholesterol. Mom is also a carrier for sickle cell and has struggled with high cholesterol, and a test by her doctor recently showed that she is heterozygous for hypercholesterolemia (hypercholesterolemia is a genetic disease that shows incomplete dominance). What are the odds of them producing a child with sickle cell disease?-------A child who is a...