Homework Answers
Aplastic anemia is a disorder of the bone marrow wherein there is pancytopenia; that is a reduction in erythrocytes, white blood cells, and platelets. This will result in arrhythmias (irregular heartbeats), enlarged heart, infections, bleeding, and sometimes death.
Cellularity of bone marrow is volume ratio of hematopoiesis and fat. In newborns, it is 100% but in adult, it varies from 30-70%. The bone marrow cellularity is severe cases of aplastic anemia is less than 25% or 25-50% with <30% residual hemopoietic cells, while in moderate cases it is less than 30%. There is no enlargement of spleen (hypersplenism) in aplastic anemia.
Right answer is B (marked decrease in cellularity of bone marrow).
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Aplastic anemia is associated with A. Marked increase in bone marrow cellularity B. Marked decrease in...
Match the following conditions with their definitions below: aplastic anemia mononucleosis sickle cell anemia hemochromatosis thalassemia...
Match the following conditions with their definitions below: aplastic anemia mononucleosis sickle cell anemia hemochromatosis thalassemia hemolytic anemia polycythemia vera hemophilia purpura 1. General increase in red blood cells (erythremia). 2. Excess iron deposits throughout the body 3. Hereditary condition characterized by abnormal crescent shape of erythrocytes and by destruction of red blood cells 4. Inherited defect in the ability to produce hemoglobin, usually seen in persons of Mediterranean background 5. Infectious disease marked by increased numbers of leukocytes and...
Colony-stimulating factors are hormones that regulate hematopoiesis. Erythropoietin (Epogen), secreted by the kidney, increases bone marrow...
Colony-stimulating factors are hormones that regulate hematopoiesis. Erythropoietin (Epogen), secreted by the kidney, increases bone marrow erythropoiesis. Granulocyte colony-stimulating factor (G-CSF) stimulates bone marrow leukopoiesis. The most recent colony-stimulating factor is thrombopoietin (TPO), which acts on bone marrow to promote the growth of platelets. These hormones are now produced biosynthetically by recombinant DNA techniques and have shown some impact in the prevention of chemotherapy-induced neutropenia, treatment of cytopenias associated with myelodysplasias, and aplastic anemia. 1. What is erythropoietin? A. A...
Select all that would be a cause of a decreased reticulocyte count.:a) newborn B)aplastic anemia C)recovery...
Select all that would be a cause of a decreased reticulocyte count.:a) newborn B)aplastic anemia C)recovery from D)acute blood loss E)hemolytic anemiafF) untreated iron deficiency G)lymphoma that has infiltrated the bone marrow
Question 15 67 50 estion 15 2 points Save Answe A patient is diagnosed with an...
Question 15 67 50 estion 15 2 points Save Answe A patient is diagnosed with an associated aplastic anemia syndrome. His bone marrow examination reveals normal cellularity with absence of erythroid precursors. What is the most likely condition? None of the above Erythroleukemia Pure red cell aplasia Fanconi's anemia Congenital dyserythropoietic anemia
7. Bone marrow (a) Describe the characteristic appearance of the bone marrow in this disorder. (b)...
7. Bone marrow (a) Describe the characteristic appearance of the
bone marrow in this disorder.
(b) Discuss the mechanism responsible for these characteristic
bone marrow findings.
8. (a) Calculate the absolute reticulocyte count - show all your
work. Is it normal or abnormal?
(b) Based on your diagnosis, is this the result you would have
expected?
9. Schilling Test Review the results of the Schilling test below
and suggest the most likely diagnosis based on these findings.
Explain your answer....
This 48-year-old woman had an unexplained anemia with low-grade fever 4 years before her death. Six...
This 48-year-old woman had an unexplained anemia with low-grade fever 4 years before her death. Six months before, bronchopneumonia developed, followed by return of severe anemia and continued pyrexia (fever). She was febrile (feverish), appeared pale, and had slight hepatomegaly and splenomegaly. Lymph nodes were palpated in the axillary and inguinal areas, and ascites developed. The chronic anemia did not respond to iron therapy. There was no evidence of blood loss or hemolysis. Diagnosis of lymphoma was confirmed by autopsy....
Where is bone marrow found? A. Inside compact bone B. Inside spongy bone C. Inside the...
Where is bone marrow found? A. Inside compact bone B. Inside spongy bone C. Inside the Haversian canal D. Inside the lamellae of the bone
___________ transplants do not require extensive HLA matching, but __________transplants do. A. Bone marrow, cornea B....
___________ transplants do not require extensive HLA matching, but __________transplants do. A. Bone marrow, cornea B. Heart, cornea C. Cornea, liver D. Liver, bone marrow
A. Discuss the importance of the bone marrow stroma for B-cell development. B. What would be...
A. Discuss the importance of the bone marrow stroma for B-cell development. B. What would be the effect of anti-IL-7 antibodies on the development of B cells in the bone marrow, and at which stage would development be impaired? Explain your answer. C. What is MHC restriction? How is it achieved during T-cell development? D. How is self-tolerance achieved during B- and T-cell development?
Congenital (autosomal recessive) aplastic anemia, characterized by low birth weight, skin pigmentation, short stature, skeletal disorders...
Congenital (autosomal recessive) aplastic anemia, characterized by low birth weight, skin pigmentation, short stature, skeletal disorders and increased chromosomal breakage is known as A. Cooley's anemia B. Fanconi anemia C. PNH D. Hereditary pyropoikilocytosis
Match the following conditions with their definitions below: aplastic anemia mononucleosis sickle cell anemia hemochromatosis thalassemia hemolytic anemia polycythemia vera hemophilia purpura 1. General increase in red blood cells (erythremia). 2. Excess iron deposits throughout the body 3. Hereditary condition characterized by abnormal crescent shape of erythrocytes and by destruction of red blood cells 4. Inherited defect in the ability to produce hemoglobin, usually seen in persons of Mediterranean background 5. Infectious disease marked by increased numbers of leukocytes and...
Colony-stimulating factors are hormones that regulate hematopoiesis. Erythropoietin (Epogen), secreted by the kidney, increases bone marrow erythropoiesis. Granulocyte colony-stimulating factor (G-CSF) stimulates bone marrow leukopoiesis. The most recent colony-stimulating factor is thrombopoietin (TPO), which acts on bone marrow to promote the growth of platelets. These hormones are now produced biosynthetically by recombinant DNA techniques and have shown some impact in the prevention of chemotherapy-induced neutropenia, treatment of cytopenias associated with myelodysplasias, and aplastic anemia. 1. What is erythropoietin? A. A...
Question 15 67 50 estion 15 2 points Save Answe A patient is diagnosed with an associated aplastic anemia syndrome. His bone marrow examination reveals normal cellularity with absence of erythroid precursors. What is the most likely condition? None of the above Erythroleukemia Pure red cell aplasia Fanconi's anemia Congenital dyserythropoietic anemia
7. Bone marrow (a) Describe the characteristic appearance of the
bone marrow in this disorder.
(b) Discuss the mechanism responsible for these characteristic
bone marrow findings.
8. (a) Calculate the absolute reticulocyte count - show all your
work. Is it normal or abnormal?
(b) Based on your diagnosis, is this the result you would have
expected?
9. Schilling Test Review the results of the Schilling test below
and suggest the most likely diagnosis based on these findings.
Explain your answer....
This 48-year-old woman had an unexplained anemia with low-grade fever 4 years before her death. Six months before, bronchopneumonia developed, followed by return of severe anemia and continued pyrexia (fever). She was febrile (feverish), appeared pale, and had slight hepatomegaly and splenomegaly. Lymph nodes were palpated in the axillary and inguinal areas, and ascites developed. The chronic anemia did not respond to iron therapy. There was no evidence of blood loss or hemolysis. Diagnosis of lymphoma was confirmed by autopsy....
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