Homework Answers
The picture shows the
reactions which are bypassed. The enzyme involved in
phosphorylation of GDP is Thiokinase.
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Certain microorganisms with an incomplete citric acid cycle decarboxylate a-ketoglutarate...
not sure about reaction 3 and 4 acetyl-CoA COA The reactions of the citric acid cycle...
not sure about reaction 3 and 4
acetyl-CoA COA The reactions of the citric acid cycle are shown in the figure Reactions 1, 3, and 4 are regulation points in the citric acid cycle. 1 citrate oxaloacetate 1 synthase citrate NADH + NAD malate dehydrogenase aconitase 2 malate Which of the molecules inhibits reaction 1? Isocitrate HO 17 fumarase NAD socitrate 3 dehydrogenase S D NADP ADP ОАТР O citrate synthase fumarate FADHI succinate co-ketoglutarate dehydrogenase ci-ketoglutarate NAD dehydrogenase +...
acetyl-CoA COA The reactions of the citric acid cycle are shown in the image. As labeled...
acetyl-CoA COA The reactions of the citric acid cycle are shown in the image. As labeled in the diagram, reactions 1, 3, and 4 are regulation points in the citric acid cycle. oxaloacetate citrate synthase citrate NADH +Hi 7 malate dehydrogenase NAD malate aconitase 2 Which molecule inhibits reaction 1? isocitrate 7 fumarase NAD isocitrate dehydrogenase 3 NADH + H+ O citrate O NAD acetyl-CoA + CO2 fumarate C-ketoglutarate FADH succinate O dehydrogenase FAD O-ketoglutarate a dehydrogenase NAD + COA...
Part B Use the structures given in the cycle shown before this part identify the enzymes involved in each step of the citric acid cycle by completing each sentence Match the words in the left column...
Part B Use the structures given in the cycle shown before this part identify the enzymes involved in each step of the citric acid cycle by completing each sentence Match the words in the left column to the appropriate blanks in the sentences on the right. View Available Hint(s) Reset Help isocitrate dehydrogenase aconitase citrate synthase fumarate hydratase succinate dehydrogenase succinyl-CoA synthetase a-ketoglutarate dehydrogenase malate dehydrogenase In step 1, oxaloacetate condenses with acetyl-CoA to form citrate, which is catalyzed by...
1. The enzyme responsible for the substrate level phosphorylation in the citric acid cycle is: a...
1. The enzyme responsible for the substrate level phosphorylation in the citric acid cycle is: a succinate dehydrogenase b. a-ketoglutarate dehydrogenase c. succinyl thiokinase d. isocitrate dehydrogenase e. aconitase 2. Which of the listed enzymes of the TCA cycle does not represent a regulatory enzyme?: a. isocitrate dehydrogenase b. succinate dehydrogenase c. malate dehydrogenase d. a-ketoglutarate dehydrogenase complex e. citrate synthase 3. Oxidative decarboxylation of pyruvic acid is regulated by: a. cyclic AMP-dependent mechanism b. cyclic AMP-independent mechanism 4. The...
Assume a cell has just completed glycolysis and the resulting pyruvate has a c-14 radio label...
Assume a cell has just completed glycolysis and the resulting
pyruvate has a c-14 radio label on carbon -1. Highlight the carbon
on the attached pages as it passes through the PDH complex and the
TCA cycle until it is lost as CO2. If only a portion of the carbons
are lost stop highlighting when the CO2 first starts to come off.
ONLY ONE TIME THRU THE CYCLE ON EACH PAGE
2. Repeat question 1 but now assume the radio...
Three of the reactions seen in the glyoxylate cycle are also citric acid cycle reactions. Which two reactions are...
Three of the reactions seen in the glyoxylate cycle are also citric acid cycle reactions. Which two reactions are unique to the glyoxylate cycle? o 1 and 2 O 2 and 3 O 3 and 4 4 and 5 5 and 1 The following diagram shows a variation of the citric acid cycle called the glyoxylate cycle. Answer the following three questions using this pathway. S-COA COO COASH NADH AG=-30 kJ/mole coo H СОО NAD* Run 5 HO- co AG=0...
Acetyl COA + H2O Coo- o coo- Citrate synthase CH2 -OH -ooc— CH2 CH2 NADH +...
Acetyl COA + H2O Coo- o coo- Citrate synthase CH2 -OH -ooc— CH2 CH2 NADH + H+ COO- Oxaloacetate Coo- Citrate Aconitase Malate dehydrogenase NAD+ - Çoo- Çoo- ---OH -O00—-H HO-CH CH2 CH2 Coo- Malate Coo- Isocitrate Isocitrate lyase Malate synthase COO- COO- Coh CH2 Acetyl COA + H2O Ho Glyoxylate coo Succinate Figure 17.23 Biochemistry, Seventh Edition 2012 W. H. Freeman and Company Question 1 (10 pts) Using diagrams show the pathway that is used to convert succinate to...
the citric acid cycle has 8 enzymes: citrate synthase, aconitase, isocitrase dehydrogenase,.... 1 Jom L C...
the citric acid cycle has 8 enzymes: citrate synthase,
aconitase, isocitrase dehydrogenase,....
1 Jom L C Tegulation TCA cycle (Ch. 16) 1. The citric acid cycle has eight enzymes: citrate synthase, aconitase, isocitrate dehydrogenase, a-ketoglutarate dehydrogenase, succinyl-CoA synthetase, succinate dehydrogenase, fumarase, and malate dehydrogenase. (a) Write a balanced equation for the reaction catalyzed by each enzyme. (b) Name the cofactor(s) required by each enzyme reaction. (c) For each enzyme determine which of the following describes the type of reaction(s) catalyzed:...
6. In mammals, which of the following does not occur during the citric acid cycle? A)...
6. In mammals, which of the following does not occur during the citric acid cycle? A) formation of a-ketoglutarate. D) metabolism of acetate to carbon dioxide and water. B) net synthesis of oxaloacetate from acetyl-CoA. E) oxidation of acetyl-CoA. C) generation of NADH and FADHz. 7. Which of the following reaction generates GTP(ATP) in the CAC? A) Isocitrate to a-ketoglutarate. D) Fumarate to Malate. B) Malate to Oxaloacetate. E) Succinyl-CoA to Succinate. C) a-ketoglutarate to Succinyl-CoA.
6. (10 pts) For the following step in the citric acid cycle, COO H COO CH...
6. (10 pts) For the following step in the citric acid cycle, COO H COO CH Succinate dehydrogenase + FAD + FADH CH, OOC H COO Succinate Fumarate a. What class of enzyme catalyzes this reaction? b. How does this step ultimately contribute to the formation of ATP? Be specific, c. Knowing that the next step is a hydration of the alkene, briefly explain why this step needed to occur? That is, why not hydrate the succinate?
not sure about reaction 3 and 4
acetyl-CoA COA The reactions of the citric acid cycle are shown in the figure Reactions 1, 3, and 4 are regulation points in the citric acid cycle. 1 citrate oxaloacetate 1 synthase citrate NADH + NAD malate dehydrogenase aconitase 2 malate Which of the molecules inhibits reaction 1? Isocitrate HO 17 fumarase NAD socitrate 3 dehydrogenase S D NADP ADP ОАТР O citrate synthase fumarate FADHI succinate co-ketoglutarate dehydrogenase ci-ketoglutarate NAD dehydrogenase +...
acetyl-CoA COA The reactions of the citric acid cycle are shown in the image. As labeled in the diagram, reactions 1, 3, and 4 are regulation points in the citric acid cycle. oxaloacetate citrate synthase citrate NADH +Hi 7 malate dehydrogenase NAD malate aconitase 2 Which molecule inhibits reaction 1? isocitrate 7 fumarase NAD isocitrate dehydrogenase 3 NADH + H+ O citrate O NAD acetyl-CoA + CO2 fumarate C-ketoglutarate FADH succinate O dehydrogenase FAD O-ketoglutarate a dehydrogenase NAD + COA...
Part B Use the structures given in the cycle shown before this part identify the enzymes involved in each step of the citric acid cycle by completing each sentence Match the words in the left column to the appropriate blanks in the sentences on the right. View Available Hint(s) Reset Help isocitrate dehydrogenase aconitase citrate synthase fumarate hydratase succinate dehydrogenase succinyl-CoA synthetase a-ketoglutarate dehydrogenase malate dehydrogenase In step 1, oxaloacetate condenses with acetyl-CoA to form citrate, which is catalyzed by...
1. The enzyme responsible for the substrate level phosphorylation in the citric acid cycle is: a succinate dehydrogenase b. a-ketoglutarate dehydrogenase c. succinyl thiokinase d. isocitrate dehydrogenase e. aconitase 2. Which of the listed enzymes of the TCA cycle does not represent a regulatory enzyme?: a. isocitrate dehydrogenase b. succinate dehydrogenase c. malate dehydrogenase d. a-ketoglutarate dehydrogenase complex e. citrate synthase 3. Oxidative decarboxylation of pyruvic acid is regulated by: a. cyclic AMP-dependent mechanism b. cyclic AMP-independent mechanism 4. The...
Assume a cell has just completed glycolysis and the resulting
pyruvate has a c-14 radio label on carbon -1. Highlight the carbon
on the attached pages as it passes through the PDH complex and the
TCA cycle until it is lost as CO2. If only a portion of the carbons
are lost stop highlighting when the CO2 first starts to come off.
ONLY ONE TIME THRU THE CYCLE ON EACH PAGE
2. Repeat question 1 but now assume the radio...
Three of the reactions seen in the glyoxylate cycle are also citric acid cycle reactions. Which two reactions are unique to the glyoxylate cycle? o 1 and 2 O 2 and 3 O 3 and 4 4 and 5 5 and 1 The following diagram shows a variation of the citric acid cycle called the glyoxylate cycle. Answer the following three questions using this pathway. S-COA COO COASH NADH AG=-30 kJ/mole coo H СОО NAD* Run 5 HO- co AG=0...
Acetyl COA + H2O Coo- o coo- Citrate synthase CH2 -OH -ooc— CH2 CH2 NADH + H+ COO- Oxaloacetate Coo- Citrate Aconitase Malate dehydrogenase NAD+ - Çoo- Çoo- ---OH -O00—-H HO-CH CH2 CH2 Coo- Malate Coo- Isocitrate Isocitrate lyase Malate synthase COO- COO- Coh CH2 Acetyl COA + H2O Ho Glyoxylate coo Succinate Figure 17.23 Biochemistry, Seventh Edition 2012 W. H. Freeman and Company Question 1 (10 pts) Using diagrams show the pathway that is used to convert succinate to...
the citric acid cycle has 8 enzymes: citrate synthase,
aconitase, isocitrase dehydrogenase,....
1 Jom L C Tegulation TCA cycle (Ch. 16) 1. The citric acid cycle has eight enzymes: citrate synthase, aconitase, isocitrate dehydrogenase, a-ketoglutarate dehydrogenase, succinyl-CoA synthetase, succinate dehydrogenase, fumarase, and malate dehydrogenase. (a) Write a balanced equation for the reaction catalyzed by each enzyme. (b) Name the cofactor(s) required by each enzyme reaction. (c) For each enzyme determine which of the following describes the type of reaction(s) catalyzed:...
6. In mammals, which of the following does not occur during the citric acid cycle? A) formation of a-ketoglutarate. D) metabolism of acetate to carbon dioxide and water. B) net synthesis of oxaloacetate from acetyl-CoA. E) oxidation of acetyl-CoA. C) generation of NADH and FADHz. 7. Which of the following reaction generates GTP(ATP) in the CAC? A) Isocitrate to a-ketoglutarate. D) Fumarate to Malate. B) Malate to Oxaloacetate. E) Succinyl-CoA to Succinate. C) a-ketoglutarate to Succinyl-CoA.
6. (10 pts) For the following step in the citric acid cycle, COO H COO CH Succinate dehydrogenase + FAD + FADH CH, OOC H COO Succinate Fumarate a. What class of enzyme catalyzes this reaction? b. How does this step ultimately contribute to the formation of ATP? Be specific, c. Knowing that the next step is a hydration of the alkene, briefly explain why this step needed to occur? That is, why not hydrate the succinate?
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