Question

Indicate whether each of the following statements (a-e) is TRUE or FALSE.  If you think a statement...

Indicate whether each of the following statements (a-e) is TRUE or FALSE.  If you think a statement is FALSE, explain why.

a.  TRUE / FALSE  Graft rejection is mediated by pre-existing host T cell effectors and antibodies specific for antigens on the grafted tissue.

b.  TRUE / FALSE  Allogeneic grafts between individuals with identical HLA genes will be accepted.

c.  TRUE / FALSE    Your parents are generally going to be your best source of tissues if you need a transplant.

d.  TRUE / FALSE    Graft rejection only occurs when alloantigens from the grafted tissue are picked-up by recipient APCs and presented to recipient T cells.

e. TRUE / FALSE   In Graft Versus Host Disease (GVHD) innate cells from the grafted tissue recognize host alloantigens and begin attacking host tissues.

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Answer #1

Ansa) false

Explanation:

Graft rejection is mediated by host t cells effectors and specific antibodies that are produced or released in response to specific antigen on the grafted tissue.

Ansb)true

Explanation: Allogeneic grafts with matching HLA gene and blood group are accepted for tissue grafting.

Ans-C)False

Explaination: successful graft or preference order of transplants:self> identical twins> siblings>parents>unrelated donor.

Ans d)false

Explanation:Graft rejection can occurs either when alloantigens from the grafted tissue are recognised directly by recipient T cells or indirectly when picked-up by recipient APCs and presented to recipient T cells.

Ans e)

True

Explanation:in GVHD the innate cell that is white blood cell from the grafted tissue recognize the host alloantigens and begin attacking host tissues.

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